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Latest Published Articles

Adaptive hypofractionated gamma knife radiosurgery for a large brainstem metastasis

Georges Sinclair, Jiri Bartek, Heather Martin, Pierre Barsoum, Ernest Dodoo

Date of publication: 10-Feb-2016

Background:To demonstrate how adaptive hypofractionated radiosurgery by gamma knife (GK) can be successfully utilized to treat a large brainstem metastasis - a novel approach to a challenging clinical situation.

Tinnitus: Is there a place for brain stimulation?

Gusta van Zwieten, Jasper V. Smit, Ali Jahanshahi, Yasin Temel, Robert J. Stokroos

Date of publication: 10-Feb-2016


Tinnitus is the perception of a “phantom sound” and has a high prevalence. Although many therapies have been investigated within the last decades, there is still no effective standard therapy. Animal studies and human functional imaging studies revealed that tinnitus perception is associated with many complex changes in multiple brain structures. There is growing evidence that brain stimulation might be able to interrupt the local altered neuronal activity and hereby inhibit tinnitus perception. In this editorial review, an update is given on the most promising targets for brain stimulation. Promising structures for stimulation are the dorsal cochlear nucleus, the inferior colliculus and the medial geniculate body of the thalamus. For cortical stimulation, the auditory cortex is considered as a target. Nevertheless, the field is waiting for evidence from well-designed clinical trials, based on supporting evidence from experimental/mechanistic research, to support or discourage the application of brain stimulation in tinnitus.

Dilemmas surrounding the diagnosis of deep brain stimulation electrode infection without associated wound complications: A series of two cases

Ha Son Nguyen, Ninh Doan, Michael Gelsomino, Saman Shabani, Wade Mueller

Date of publication: 10-Feb-2016

Background:When wounds are benign, diagnosis of deep brain stimulation (DBS) electrode infection and associated intraparenchymal infection can be challenging. Only a couple, such cases exist in literature. Since infections of the central nervous system can be life-threatening, prompt diagnosis is necessary to prevent neurological injury. Employed within the appropriate context, magnetic resonance imaging (MRI) of the brain, as well as laboratory data and clinical presentation, may help guide diagnosis.

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