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Latest Published Articles

A comprehensive review of amyotrophic lateral sclerosis

Sara Zarei, Karen Carr, Luz Reiley, Kelvin Diaz, Orleiquis Guerra, Pablo Fernandez Altamirano, Wilfredo Pagani, Daud Lodin, Gloria Orozco, Angel Chinea

Date of publication: 16-Nov-2015


Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5–10% of the cases are familial ALS. Both sporadic and familial ALS (FALS) are associated with degeneration of cortical and spinal motor neurons. The etiology of ALS remains unknown. However, mutations of superoxide dismutase 1 have been known as the most common cause of FALS. In this study, we provide a comprehensive review of ALS. We cover all aspects of the disease including epidemiology, comorbidities, environmental risk factor, molecular mechanism, genetic factors, symptoms, diagnostic, treatment, and even the available supplement and management of ALS. This will provide the reader with an advantage of receiving a broad range of information about the disease.

A rare case of giant multiseptated thoracic myelomeningocele with segmental placode

Ashis Patnaik, Ashok Kumar Mahapatra

Date of publication: 16-Nov-2015

Microsurgical treatment of patients with refractory epilepsy and mesial temporal cavernous malformations: Clinical experience of a tertiary epilepsy center

Lucas Crociati Meguins, Rodrigo Antônio Rocha da Cruz Adry, Sebastião Carlos da Silva Júnior, Carlos Umberto Pereira, Jean Gonçalves de Oliveira, Dionei Freitas de Morais, Gerardo Maria de Araújo Filho, Lúcia Helena Neves Marques

Date of publication: 16-Nov-2015

Background:Mesiotemporal cavernous malformation can occur in 10–20% of patients with cerebral cavernomas and are frequently associated with refractory.

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