Deep brain stimulation for obsessive-compulsive disorder: Knowledge and concerns among psychiatrists, psychotherapists and patients
- Department of Clinical Sciences/Psychiatry, Umeå University, Sweden
- Unit of Deep Brain Stimulation, Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
- Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, United Kingdom
Department of Clinical Sciences/Psychiatry, Umeå University, Sweden
DOI:10.4103/sni.sni_19_17Copyright: © 2017 Surgical Neurology International This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Matilda Naesström, Patric Blomstedt, Marwan Hariz, Owe Bodlund. Deep brain stimulation for obsessive-compulsive disorder: Knowledge and concerns among psychiatrists, psychotherapists and patients. 06-Dec-2017;8:298
How to cite this URL: Matilda Naesström, Patric Blomstedt, Marwan Hariz, Owe Bodlund. Deep brain stimulation for obsessive-compulsive disorder: Knowledge and concerns among psychiatrists, psychotherapists and patients. 06-Dec-2017;8:298. Available from: http://surgicalneurologyint.com/?post_type=surgicalint_articles&p=8698
Background:Deep brain stimulation (DBS) is under investigation for severe obsessive-compulsive disorder (OCD) resistant to other therapies. The number of implants worldwide is slowly increasing. Therefore, it is of importance to explore knowledge and concerns of this novel treatment among patients and their psychiatric healthcare contacts. This information is relevant for scientific professionals working with clinical studies for DBS for this indication. Especially, for future study designs and the creation of information targeting healthcare professionals and patients. The aim of this study was to explore the knowledge and concerns toward DBS among patients with OCD, psychiatrists, and cognitive behavioral therapists.
Methods:The study was conducted through web-based surveys for the aimed target groups –psychiatrist, patients, and cognitive behavioral therapists. The surveys contained questions regarding previous knowledge of DBS, source of knowledge, attitudes, and concerns towards the therapy.
Results:The main source of information was from scientific sources among psychiatrists and psychotherapists. The patient's main source of information was the media. Common concerns among the groups included complications from surgery, anesthesia, stimulation side effects, and the novelty of the treatment. Specific concerns for the groups included; personality changes mentioned by patients and psychotherapists, and ethical concerns among psychiatrists.
Conclusion:There are challenges for DBS in OCD as identified by the participants of this study; source and quality of information, efficacy, potential adverse effects, and eligibility. In all of which the current evidence base still is limited. A broad research agenda is needed for studies going forward.
Keywords: Attitude, deep brain stimulation, obsessive-compulsive disorder, patient, psychiatrist, psychotherapist
Obsessive-compulsive disorder (OCD) is a chronic disorder affecting approximately 2% of the population. The disorder is characterized by persistent obsessive, intrusive thoughts generating anxiety, and related compulsions (tasks or “rituals”) with the function of neutralizing the distress.[
New treatments are currently under evaluation, including deep brain stimulation (DBS), which modulates brain circuits hypothesized to be implicated in OCD. DBS is an established treatment for severe therapy-refractory Parkinson's disease, dystonia, and essential tremor and is currently evaluated for a number psychiatric disorders.[
DBS trials for psychiatric conditions require collaboration between multidisciplinary teams highly specialized in DBS, participating patients, primary psychiatric healthcare providers, and often also involvement of other caretakers and family members. This invasive and probably life-long treatment, differs considerably from the established therapies, and was in one study ranked as the least preferred novel treatment among inpatients with OCD.[
Few publications have been presented regarding quality of life and experiences in OCD patients after treatment with DBS.[
The study was conducted through a web-based survey, specifically aimed to psychiatrists, cognitive behavioral therapy (CBT) psychotherapists, and patients with OCD. Given the relatively small sample sizes, and the paucity of previous research in this area, the study was exploratory.
Three web-based surveys were constructed for psychiatrist, therapists with experience of CBT, and OCD patients, respectively. The surveys contained questions concerning age, sex, previous knowledge of DBS, source of knowledge, attitudes, and concerns towards the therapy. The patient survey included additional questions regarding self-assessed severity of the disorder and current treatment regime. The link to the web-survey was distributed among psychiatrists in the northern region of Sweden and a national CBT psychotherapist group. For patients with OCD, a link was published at the website of the national Swedish OCD patient-support group. The data was analyzed using the statistical tool SPSS, version 22. The project was approved by the Umeå ethics board.
A total of 65 patients with OCD, 44 psychiatrists, and 52 psychotherapists answered the survey. Characteristics of the target groups, sources of information, and concerns are presented in Tables
In response to the question how large an impairment OCD had on their social and professional life 3.1% answered no, 15.4% minor, 24.6% moderate, 41.5% major, and 15.4% extreme impairment. Of the patients 38.5% had a combination of pharmacological therapy and psychotherapy, 35.4% only pharmacological therapy and 7.7% only psychotherapy; while 18.5% received no current treatment. 58.5% of the patients were positive to consider undergoing DBS for OCD. Males were more positive than females (P value 0.05, Pearson's Chi-squared test), but no differences were seen regarding age. The most common concerns regarding DBS are presented in
Of the responders 57% were certified psychiatrists and 43% under specialist-training in psychiatry. 93.2% had knowledge of DBS for OCD prior to the survey. After being presented with a list of inclusion criteria for DBS (diagnosis of severe and debilitating OCD and nonresponse to trial of CBT and at least three seretonin reuptake inhibitors (SRI) trials, including with augmentation of a neuroleptic) 50% estimated that among their patients 2–5 fulfilled these criteria, 34% 6–10 patients fulfilling the criterion, 14% >10 patients, and 2% no patients. A majority (95%), were positive to refer patients with OCD for DBS.
Cognitive behavioral therapy psychotherapists
All responders had experiences with CBT for OCD, 46% had a degree in psychology and the remainder had additional training in CBT. After being presented with a list of inclusion and exclusion criteria for DBS in OCD 54% estimated that their clinic had no patients that could fulfill these criteria, 38% 2–5 patients, 4% 6–10 patients, and 4% >10 patients. 94% were positive to DBS for OCD.
Knowledge of deep brain stimulation
Of the OCD patients 29% had knowledge of DBS prior to the survey. The majority had obtained this information through media and there was a nonsignificant trend suggesting that patients with previous knowledge of DBS were more positive to undergoing such treatment.
It has previously been pointed out that patients educate themselves and build their hopes from uncritical media sources, which might be an issue since media cover on DBS usually is overly optimistic with minimal coverage of risks.[
This highlights the importance of establishing a dialogue between experts and the general public to foster a better understanding of the possibilities and limitations of DBS. Ultimately, scientists and physicians in the field need to consider the public portrayal of DBS for OCD, to ensure realistic hopes.
In comparison, the main source of information for psychiatrists and psychotherapists consisted scientific sources and colleagues. The waste majority of psychiatrists (93.1%) and almost half of the CBT therapists (40.3%) had previous knowledge of DBS. This could reflects the high interest for the field, which can be seen in the increasing number of publications related to DBS for psychiatric indications.[
Considering the novelty and invasiveness of DBS in psychiatry, a majority of psychiatrists (95%), CBT psychotherapists (94%), and OCD patients (58.5%) were positive to DBS as a therapy for OCD. However, there is a risk for selection bias with primarily individuals with an interest in DBS participating in the study. That over half of the patients could consider treatment with DBS contrasts with a previous study from 2010 by Patel et al., where DBS was ranked as the least preferred investigational treatment among patients with OCD.[
The positive attitude towards DBS among psychiatrists and CBT psychotherapists is reassuring considering the potential need for medical follow-up for future DBS OCD patients in their own community. Two commonly mentioned concerns among psychiatrist were resistance to neurosurgery among potential patients and the difficulty to identify eligible candidates. This could represent a lack of knowledge of selection criteria for OCD trials and risks, and possibilities of DBS. Strategies to communicate selection criteria for patient referral to psychiatrist and to develop clear psychiatric postsurgical follow-up strategies for the patients’ primary psychiatric contacts will be needed in the future. It will further be of importance to optimize care and transfer of knowledge to local psychiatric health contacts for this novel patient group. Furthermore, CBT has been suggested as a promising augmentation of DBS in OCD.[
Concerns regarding deep brain stimulation
Complications from surgery and anesthesia was a common concern in all three groups. This is similar to Leykin et al., where participants in a DBS-trial for treatment-resistant depression correctly identified the surgery itself as the riskiest part of the study.[
Side-effects of the stimulation were a main concern in the patient group. Compared to the extensive data on surgical complications, there is limited knowledge about the potential stimulation related adverse effects of DBS in psychiatric patients. Multiple different anatomical targets are under evaluation in OCD (nucleus accumbens, ventral capsule/ventral striatum, subthalamic nucleus, internal capsule, inferior thalamic peduncle, bed nucleus of stria terminalis) and they differ in probability and quality of stimulation induced side-effects.[
The possibility of DBS-induced personality changes was the second most common concern among CBT psychotherapists and the third concern in the patient group. The concept of personality is complex and it is not possible from this survey to know what the groups would define as a personality change. However, the possibility of stimulation induced changes in personality is currently one of the most discussed clinical side effect and ethical concern for DBS in psychiatric indications.[
The use of DBS in OCD and other psychiatric disorders faces a number of unique ethical challenges and concerns, which is not surprising considering the historical legacy of surgery in this group of patients. Hence, it is reassuring that the field appears to be aware of this issue, considering the topic is regularly discussed in the literature.[
Eligibility for referral to deep brain stimulation
Considering eligibility of patients, over half of the psychotherapists reported that they had no OCD patients that would fulfill the presented inclusion criteria for DBS. This was in contrast to the psychiatrists, where only 2% estimated that they had no patients fulfilling the inclusion criteria. This discrepancy could be due to psychotherapists encountering patients motivated and eligible for CBT therapy, hence with a less severe form of the disorder, while psychiatrists might encounter a greater diversity of OCD patients, including some with severe symptoms. A study using data from a naturalistic clinical sample found that meeting the stringent criteria to qualify for DBS is rare among the general OCD population.[
The interest and research in DBS in psychiatric disorders have surged the past half-decade since the first publication of Nuttin et al. in 1999, and the therapy is hoped to have the potential to relieve symptoms in some of the most disabling disorders known to humankind.[
The main limitation of the study is the small sample size, which limited the type of analyses that could be performed, as well as the interpretations that could be made. In addition, there is a risk for selection bias, in the sense that the subjects who chose to participate could already have an interest in DBS. Further, it is possible that the attitude towards DBS for psychiatric disorders differ between countries, due to cultural differences and historical experiences of other forms of psychosurgery. Hence, the sample might not be representative for the targeted groups in other countries. The aim was to obtain an overview of the quality and variety of the concerns with DBS in OCD, and not necessarily to provide a representative quantification. Further studies are needed to examine the knowledge and concerns about DBS in OCD across a broader sample.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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