{"id":"7e17db2a-d854-48a5-bdb0-3c3cfea8f4fa","slug":"11c-methionine-and-18f-fdg-pet-double-negative-metastatic-brain-tumor-from-lung-adenocarcinoma-with-paradoxical-high-18f-fdg-uptake-a-case-report","title":"<sup>11</sup>C-methionine- and <sup>18</sup>F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high <sup>18</sup>F-FDG uptake: A case report","authors":["Kuniaki Tanahashi","Masaki Hirano","Lushun Chalise","Takahiko Tsugawa","Yuka Okumura","Tetsunari Hase","Fumiharu Ohka","Kazuya Motomura","Kazuhito Takeuchi","Yuichi Nagata","Norimoto Nakahara","Naozumi Hashimoto","Ryuta Saito"],"abstract":"Background: Imaging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and 11C-methionine (MET)-PET can delineate primary and metastatic brain tumors. Lesion size affects the sensitivity of both scans and histopathological features can also influence FDG-PET, but the effects on MET-PET have not been elucidated. Case Description: We report an unusual case of metastatic brain tumors without accumulation of FDG or MET, contrasting with high FDG uptake in the primary lung lesion. The brain lesions were identified as adenocarcinoma with a more mucus-rich background, contributing to the indistinct accumulation of both FDG and MET. Conclusion: Histopathological characteristics can affect both MET and FDG accumulation, leading to findings contradicting those of the primary lesion.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/7e17db2a-d854-48a5-bdb0-3c3cfea8f4fa/featured/hero-1781561065557.png","publishDate":"2022-08-19T00:00:00.000Z","doi":"10.25259/SNI_264_2022","categories":["Unique Case Observations","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/08/11804/SNI-13-372.pdf"}