{"id":"04913667-b6ca-4af0-a728-6ec07b073d36","slug":"after-19-years-of-deep-brain-stimulation-in-tourettes-syndrome-from-multiple-targets-to-one-single-target","title":"After 19 years of deep brain stimulation in Tourette’s syndrome: From multiple targets to one single target?","authors":["Domenico Servello","Christian Saleh","Alberto R. Bona","Edvin Zekaj","Mauro Porta"],"abstract":"Background: Deep brain stimulation (DBS) for Tourette's syndrome (TS) lacks a consensus on target selection, with multiple potential targets proposed. Historically, the thalamic centromedian-parafascicular nucleus (CM/Pf) was first suggested for DBS in TS in 1999, but various targets have since emerged, reflecting the complexity of the disorder and its comorbidities. Summary: Clinicians have increasingly focused on controlling comorbidities associated with TS, leading to a shift in target selection based on individual patient phenotypes. The anterior globus pallidus internus (a-GPi) has shown promise in managing both motor tics and associated behavioral symptoms, demonstrating stable long-term responses and a lower risk of hardware-related complications compared to other targets. Conclusion: Standardization of target selection in DBS for TS is essential for improving patient care. Based on extensive data, the a-GPi appears to be a viable single target for treatment, warranting further attention and consensus within the DBS community. Keywords: Tourette's syndrome, deep brain stimulation, target selection, globus pallidus internus, thalamic stimulation, comorbidities, motor tics, behavioral symptoms","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/04913667-b6ca-4af0-a728-6ec07b073d36/featured/hero-1782420808484.png","publishDate":"2018-10-30T00:00:00.000Z","doi":"10.4103/sni.sni_271_18","categories":["Stereotactic","Editorial"],"fullTextUrl":"http://surgicalneurologyint.com/wp-content/uploads/2018/11/9056/SNI-9-219.pdf"}