{"id":"4afc7b40-5b14-424e-b92b-bfe6d86bef69","slug":"astrocytoma-with-high-grade-features-and-mybl1-mmp16-fusion","title":"Astrocytoma with high-grade features and MYBL1-MMP16 fusion","authors":["Abdullah Alarfaj","Brooke Pollock","Abdelaziz Sagga","Sumit Das","Michael Chow"],"abstract":"Background: Gliomas represent the most common primary intraparenchymal brain tumors in adult and pediatric patients. Neuropathological work-up of these gliomas typically entails the determination of isocitrate dehydrogenase (IDH) mutational status, presence or absence of 1p/19q co-deletion, and O6 methylguanine-DNA methyl-transferase (MGMT) promoter methylation status. Case Description: We present here an unusual case of a posterior fossa tumor in a 51-year-old female, which was initially diagnosed as astrocytoma with some high-grade features that recurred, displaying even more aggressive features such as infiltration and increased proliferative activity. Both the initially resected and recurrent tumor revealed MYBL1-MMP16 fusion, which is much more commonly found in pediatric low-grade gliomas and, to our knowledge has not been described in the context of an adult glioma. Conclusion: The significance of MYBL1-MMP16 fusion in adult gliomas in relation to survival and likelihood of recurrence is, therefore, unknown and requires more extensive research.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/4afc7b40-5b14-424e-b92b-bfe6d86bef69/featured/hero-1781559444942.png","publishDate":"2024-06-21T00:00:00.000Z","doi":"10.25259/SNI_465_2023","categories":["Neuropathology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2024/06/12959/SNI-15-203.pdf"}