{"id":"6ca45872-9360-4236-9a14-31287933f0a4","slug":"atypical-meningioma-as-a-solitary-malignancy-in-a-patient-with-rothmund-thompson-syndrome","title":"Atypical meningioma as a solitary malignancy in a patient with Rothmund-Thompson syndrome","authors":["Niv Pencovich","Nevo Margalit","Shlomi Constantini"],"abstract":"Background: Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by genomic instability and increased risk of various malignancies, especially osteosarcoma and squamous cell carcinoma. We report the first RTS patient who developed a central nervous system (CNS)-related neoplasm. Case description: A 28-year-old male, previously diagnosed with RTS , developed a massive parasagital lesion, detected by magnetic resonance imaging. The tumor was surgically removed and histologically diagnosed as atypical meningioma. Preoperative symptoms were dramatically improved. Conclusions: This is the first description of a CNS-related malignancy in RTS patients. Although rare, the genomic instability and additional risk factors of this syndrome should be considered in choosing the course of treatment.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/6ca45872-9360-4236-9a14-31287933f0a4/featured/hero-1782420978477.png","publishDate":"2012-12-14T00:00:00.000Z","doi":"10.4103/2152-7806.104742","categories":["Original Article"],"fullTextUrl":"http://sni.wpengine.com/wp-content/uploads/2015/05/3488/SNI-3-148.pdf"}