{"id":"23bc82cb-96fd-4931-ac76-c080a00f89ed","slug":"case-report-and-review-of-the-literature-of-primary-central-nervous-system-lymphoma-of-the-fourth-ventricle","title":"Case report and review of the literature of primary central nervous system lymphoma of the fourth ventricle","authors":["Yuichiro Kojima","Kosuke Nakajo","Tsutomu Ichinose","Yoichiro Morikawa","Masahiko Osawa","Takeo Goto"],"abstract":"Background: Primary central nervous system lymphoma of the fourth ventricle is very rare. We present a case of primary central nervous system lymphoma originating from the fourth ventricle and review cases reported in the literature. Case Description: A 54-year-old man with no previous medical history presented with headache and nausea. Magnetic resonance imaging showed a homogeneously enhancing tumor in the fourth ventricle and obstructive hydrocephalus. We performed biopsy of the tumor, which was diagnosed pathologically as diffuse large B-cell lymphoma. Although the tumor disappeared after 5 cycles of R-MPV regimen, the patient required repeated ventricular drainage and finally received a ventriculoperitoneal shunt. Complete response was achieved after 2 cycles of high-dose cytarabine chemotherapy with an autologous peripheral blood stem cell transplant. There was no sign of recurrence at 20 months after biopsy. Conclusion: Morbidity arising due to radical resection/radiotherapy of resistant primary central nervous system lymphoma originating from the fourth ventricle could be prevented by ventriculoperitoneal shunting with chemotherapy and autologous blood stem cell transplantation.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/23bc82cb-96fd-4931-ac76-c080a00f89ed/featured/hero-1781560760901.png","publishDate":"2022-11-11T00:00:00.000Z","doi":"10.25259/SNI_654_2022","categories":["Neuro-oncology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/11/11987/SNI-13-529.pdf"}