{"id":"5cc74838-ffea-4b38-8050-5cf846ed2823","slug":"clinically-useful-tumor-fluorescence-greater-than-24-hours-after-5-aminolevulinic-acid-administration","title":"Clinically useful tumor fluorescence greater than 24 hours after 5-aminolevulinic acid administration","authors":["Sameah Haider","Travis Matthew Hamilton","Rachel J. Hunt","Ian Y. Lee","Adam M. Robin"],"abstract":"Background: 5-aminolevulinic acid (5-ALA) is a valuable surgical adjuvant used for the resection of glioblastoma multiforme (GBM). Since Food and Drug Administration approval in 2017, 5-ALA has been used in over 37,000 cases. The current recommendation for peak efficacy and intraoperative fluorescence is within 4 h after administration. This narrow time window imposes a perioperative time constraint which may complicate or preclude the use of 5-ALA in GBM surgery. Case Description: This case report describes the prolonged activity of 5-ALA in a 66-year-old patient with a newly diagnosed GBM lesion within the left supramarginal gyrus. An awake craniotomy with language and sensorimotor mapping was planned along with 5-ALA fluorescence guidance. Shortly, after receiving the preoperative 5-ALA dose, the patient developed a fever. Surgery was postponed for an infectious disease workup which proved negative. The patient was taken to surgery the following day, 36 h after 5-ALA administration. Despite the delay, intraoperative fluorescence within the tumor remained and was sufficient to guide resection. Postoperative imaging confirmed a gross total resection of the tumor. Conclusion: The use of 5-ALA as an intraoperative adjuvant may still be effective for patients beyond the recommended 4-h window after initial administration. Reconsideration of current use of 5-ALA is warranted.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/5cc74838-ffea-4b38-8050-5cf846ed2823/featured/hero-1781561528003.png","publishDate":"2022-03-25T00:00:00.000Z","doi":"10.25259/SNI_836_2021","categories":["Neuro-oncology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/03/11491/SNI-13-99.pdf"}