{"id":"baa82c71-18a5-4490-970a-8ad512b66a21","slug":"comparison-of-postoperative-delirium-in-patients-anesthetized-with-isoflurane-versus-desflurane-during-spinal-surgery-a-prospective-randomized-controlled-trial","title":"Comparison of postoperative delirium in patients anesthetized with isoflurane versus desflurane during spinal surgery: A prospective randomized controlled trial","authors":["Steve Joys","Tanvir Samra","Vishal Kumar","Manju Mohanty","Harsimrat B. S. Sodhi","Shalvi Mahajan","Hemant Bhagat"],"abstract":"Background: Following spine surgery, different types of inhalational anesthetic agents can result in postoperative delirium (POD) that can increase perioperative/postoperative morbidity. Here, we compared the incidence of POD in adults undergoing spine surgery anesthetized with isoflurane versus desflurane. Methods: A prospective randomized double-blind clinical trial for patients undergoing spinal surgery was performed in 60 adults (aged 18–65 years); they were randomized to receive isoflurane or desflurane. On postoperative days 1 and 3, the diagnosis and severity of POD utilized 3D-Confusion Assessment Method (CAM) and CAM-severity delirium severity scores to assess patients’ status. Multiple other variables which may have influenced the frequency/severity of POD were also studied. Results: For the two groups, the incidence of POD utilizing isoflurane and desflurane was similar on postoperative days 1 (10% vs. 13.3%, P > 0.05) and 3 (6.6% vs. 0%, P > 0.05). The severity scores of POD for both anesthetic agents were also similar on postoperative days 1 (1.5 vs. 1) and 3 (0.5 vs. 0.5). In addition, there was no significant association of POD with other perioperative factors. Conclusion: A significant number of patients undergoing spine surgery experience POD. However, the incidence and severity of POD remained similar when utilizing either isoflurane or desflurane.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/baa82c71-18a5-4490-970a-8ad512b66a21/featured/hero-1781563700500.png","publishDate":"2019-11-22T00:00:00.000Z","doi":"10.25259/SNI_287_2019","categories":["Spine","Original Article"],"fullTextUrl":"http://surgicalneurologyint.com/wp-content/uploads/2019/11/9770/SNI-10-226.pdf"}