{"id":"922d15ad-04ad-4a35-a42e-fcf9ff1c29be","slug":"converging-paths-to-progress-for-skull-base-chordoma-review-of-current-therapy-and-future-molecular-targets-2","title":"Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets","authors":["Salvatore Di Maio","Esther Kong","Stephen Yip","Robert Rostomily"],"abstract":"Background: Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures. Methods: A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials. Results: A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions. Conclusion: Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight into the collaborative approach applied to orphan diseases, of which chordomas is a prime exemplar.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/922d15ad-04ad-4a35-a42e-fcf9ff1c29be/featured/hero-1782420958368.png","publishDate":"2013-06-01T00:00:00.000Z","doi":"10.4103/2152-7806.112822","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/922d15ad-04ad-4a35-a42e-fcf9ff1c29be/pdf"}