{"id":"203c00a5-a705-44e2-9979-7e7092ecd4b6","slug":"cranial-and-spinal-leptomeningeal-dissemination-in-esthesioneuroblastoma-two-reports-of-distant-central-nervous-system-metastasis-and-rationale-for-treatment","title":"Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment","authors":["Walavan Sivakumar","Nathan Oh","Aaron Cutler","Howard Colman","William T. Couldwell"],"abstract":"Background: Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination. Case Description: The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success. Conclusion: Understanding the drivers of leptomeningeal dissemination in more prevalent primary neuroectodermal tumors may hold the key to developing successful treatment algorithms for this disease.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/203c00a5-a705-44e2-9979-7e7092ecd4b6/featured/hero-1782420954687.png","publishDate":"2015-11-25T00:00:00.000Z","doi":"10.4103/2152-7806.170464","categories":["Unique Case Observations","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/203c00a5-a705-44e2-9979-7e7092ecd4b6/pdf"}