{"id":"35807889-5651-44b6-b26b-ffd1e9d65e0a","slug":"decompressive-craniectomy-for-malignant-middle-cerebral-artery-infarction-impact-on-mortality-and-functional-outcome","title":"Decompressive craniectomy for malignant middle cerebral artery infarction: Impact on mortality and functional outcome","authors":["Mohammad Azman Mohammed Raffiq","Mohammed Saffari Mohammad Haspani","Regunath Kandasamy","Jafri Malin Abdullah"],"abstract":"Background: Malignant middle cerebral artery (MCA) infarction is a devastating clinical entity affecting about 10% of stroke patients. Decompressive craniectomy has been found to reduce mortality rates and improve outcome in patients. Methods: A retrospective case review study was conducted to compare patients treated with medical therapy and decompressive surgery for malignant MCA infarction in Hospital Kuala Lumpur over a period of 5 years (from January 2007 to December 2012). A total of 125 patients were included in this study; 90 (72%) patients were treated with surgery, while 35 (28%) patients were treated with medical therapy. Outcome was assessed in terms of mortality rate at 30 days, Glasgow Outcome Score (GOS) on discharge, and modified Rankin scale (mRS) at 3 and 6 months. Results: Decompressive craniectomy resulted in a significant reduction in mortality rate at 30 days (P P P P < 0.05). Age and dominant hemisphere infarction had no significant association with functional outcome. Conclusion: Decompressive craniectomy achieves good functional outcome in, young patients with good preoperative GCS score and favorable radiological findings treated with surgery within 24 h of ictus.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/35807889-5651-44b6-b26b-ffd1e9d65e0a/featured/hero-1782420835301.png","publishDate":"2014-06-26T00:00:00.000Z","doi":"10.4103/2152-7806.135342","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/35807889-5651-44b6-b26b-ffd1e9d65e0a/pdf"}