{"id":"aa7eaac3-ccd2-44a1-b081-5ba1d5e6ea10","slug":"destructive-spondylodiscitis-associated-with-sapho-syndrome-a-case-report-and-literature-review","title":"Destructive spondylodiscitis associated with SAPHO syndrome: A case report and literature review","authors":["Shu Takeuchi","Junya Hanakita","Toshiyuki Takahashi","Manabu Minami","Ryo Kanematsu","Izumi Suda","Sho Nakamura"],"abstract":"Background: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare sterile inflammatory disease characterized by cutaneous and osteoarticular lesions. Associated spinal lesions chronically manifest slight or no neurological symptoms. Only rarely does destructive spondylodiscitis occur. Case Description: A 62-year-old female with palmoplantar pustulosis presented with a rapidly progressive quadriparesis. When the cervical MR showed destructive spondylodiscitis at the C5–C7 level, the patient underwent anterior debridement followed by posterior reconstruction/fixation. The histopathology showed a nonspecific inflammatory process with vertebral sclerosis consistent with the diagnosis of SAPHO; cultures were negative. Postoperatively, the patient’s symptoms improved and SAPHO did not recur. Conclusion: Destructive spondylodiscitis associated with SAPHO syndrome is uncommon. Early diagnosis and surgical treatment result in the best outcomes.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/aa7eaac3-ccd2-44a1-b081-5ba1d5e6ea10/featured/hero-1781561118243.png","publishDate":"2022-08-05T00:00:00.000Z","doi":"10.25259/SNI_626_2022","categories":["Spine","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/08/11761/SNI-13-345.pdf"}