{"id":"6c6d999c-7f36-4efb-9ef3-f3a1a02a2f53","slug":"do-mesothelinmuc16-interactions-facilitate-adenocarcinoma-metastases-to-intracranial-meningiomas","title":"Do mesothelin/MUC16 interactions facilitate adenocarcinoma metastases to intracranial meningiomas?","authors":["Mahlon D. Johnson"],"abstract":"Background: Meningiomas have been shown to express mesothelin, a high affinity binding site for MUC16, a transmembrane protein on adenocarcinoma cells. The mechanisms underlying adenocarcinoma metastases to meningiomas may provide insight into tumor-to-tumor metastases and adenocarcinoma metastases to leptomeningeal cells. Methods: Two meningiomas containing metastases from adenocarcinomas were identified and evaluated immunohistochemically for the expression and localization of mesothelin and MUC16. Results: Both meningiomas show extensive mesothelin immunoreactivity, and the adenocarcinomas metastatic to the meningiomas show mesothelin and MUC16 immunoreactivity at the interface with meningioma. Conclusions: Interactions between MUC16 and/or mesothelin on the cell membrane of adenocarcinoma cells with mesothelin on meningioma cells may facilitate adenocarcinoma metastases to meningiomas and possibly the leptomeninges.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/6c6d999c-7f36-4efb-9ef3-f3a1a02a2f53/featured/hero-1782420892614.png","publishDate":"2016-12-21T00:00:00.000Z","doi":"10.4103/2152-7806.196367","categories":["Neurovascular","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/6c6d999c-7f36-4efb-9ef3-f3a1a02a2f53/pdf"}