{"id":"f8506261-61fc-4950-b906-302e20e7db4a","slug":"efficacy-of-high-dose-versus-low-dose-tranexamic-acid-for-reduction-of-blood-loss-in-adolescent-idiopathic-scoliosis-surgery-a-systematic-review-and-meta-analysis","title":"Efficacy of high-dose versus low-dose tranexamic acid for reduction of blood loss in adolescent idiopathic scoliosis surgery: A systematic review and meta-analysis","authors":["Abdulsalam Mohammed Aleid","Haneen Saleh Saeed","Saud Nayef Aldanyowi","Loai Albinsaad","Mohammed Alessa","Hasan AlAidarous","Zainab Aleid","Abbas Almutair"],"abstract":"Background: Recent studies have suggested that high-dose tranexamic acid (TXA) may be an effective method for reducing blood loss during adolescent idiopathic scoliosis (AIS) surgery. This study aims to perform a systematic review and meta-analysis to compare the outcomes of high-dose versus low-dose TXA for AIS surgery. Methods: Searches were conducted in major databases such as PubMed, Scopus, Google Scholar, and Cochrane Library for relevant studies comparing high-dose and low-dose TXA outcomes in terms of blood loss, red blood cell transfusions, and hemoglobin changes. This systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered with PROSPERO (CRD42024547735). Results: Four studies were included, published between 2009 and 2022, encompassing a total of 531 patients. High-dose TXA showed less blood loss compared to low-dose TXA, with a pooled mean difference of −0.40 (95% CI, −0.79–−0.01). Neither the volume of blood products used nor the decrease in hemoglobin levels showed significant differences between the groups. Conclusion: High-dose TXA appears to be more effective in reducing blood loss during AIS surgery compared to low-dose TXA. Further robust clinical trials with larger sample sizes are necessary to confirm these results and establish optimal dosing regimens for maximizing efficacy while ensuring safety.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/f8506261-61fc-4950-b906-302e20e7db4a/featured/hero-1781558967504.png","publishDate":"2024-12-27T00:00:00.000Z","doi":"10.25259/SNI_644_2024","categories":["General Neurosurgery","Review Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/f8506261-61fc-4950-b906-302e20e7db4a/pdf"}