{"id":"8ac8b54b-0373-4cd3-b59b-ead15fac6770","slug":"endoscopic-endonasal-transcavernous-approach-for-removal-of-pituitary-macroadenoma-with-apoplexy-technical-nuances","title":"Endoscopic endonasal transcavernous approach for removal of pituitary macroadenoma with apoplexy: Technical nuances","authors":["Adnan Hussain Shahid","Mehdi Khaleghi","Sudhir Suggala","Garrett Dyess","Danner Warren Butler","Ursula Hummel","Mark Richard Gacek","Jai Deep Thakur"],"abstract":"Background: The endoscopic endonasal transcavernous approach is an extended approach for sellar masses with cavernous invasion with negligible complications regarding permanent cranial nerve (CN) palsy or internal carotid artery (ICA) injury. With a proper understanding of surgical anatomy regarding the ICA and its relation to the cavernous sinus, an endoscopic trans-cavernous approach through the anterior wall of the cavernous sinus with lateral and superior extension can allow for safe and efficient tumor visualization and removal in the inferior and superior CS compartment. The aim is to describe the technical nuances involved during the transvenous approach. Case Description: A 67-year-old male with acute onset of left vision loss, headache, and left side complete CN III and VI palsy with large sellar mass measuring 3.1 × 2.0 × 5.6 cm extending to the left cavernous sinus encasing the ICAs with evidence of apoplexy. An endonasal transcavernous approach was done involving tumor removal from the superior and inferior compartment, resulting in gross total resection. Histological examination revealed a nonfunctioning apoplectic pituitary adenoma. The patient was discharged on Post-operative day (POD) 2 with partial palsy in CN III and CN VI and was noted to have a progressive improvement in CN palsy with complete resolution of ptosis and partial palsy of CN VI at the 3-month follow-up visit. Conclusion: Pseudocapsular apoplectic plane identification, extracapsular dissection, identification of parasellar ligaments, and understanding of adenoma-cavernous sinus ICA relationship are key surgical highlights that we discuss in our case. The combination of these techniques, along with the use of intraoperative Doppler, helped us to maximize pituitary gland preservation, CN improvement, and gross total resection of a large pituitary adenoma with cavernous sinus invasion presenting as apoplexy. Future studies with endoscopic endonasal transvenous approaches with cavernous sinus extension for large pituitary adenoma with apoplexy are warranted to study long-term CN outcomes. Note: Two images, used from Rhoton collection” website: https://www.aans.org/education-publications/references/the-rhoton-collection/ ” Endoscopic Endonasal Transcavernous Approach for Removal of Pituitary Macroadenoma with Apoplexy 000.13 – Clinical presentation 0.00.35 – Pre-op Neuroimaging 0.01.03 – Rationale for the procedure 000.59 – Potential benefits and risks of the procedure 01.27 – Alternatives and reasons such approaches were not chosen 02.09 – Procedure set up 01.49 – Key surgical steps 03.06 – Surgical video 03.07 – Identification of Cavernous ICA 03.15 – Opening of Sellar dura 03.45 – Extracapsular dissection of tumor 03.57 – Left side cavernous sinus opening 04.27 – Inferior compartment dissection 04.49 – Superior compartment dissection 05.23 – Falling of diaphragma sellae 06.17 – Imaging Outcome 06.35 – Progress or Clinical Outcome The Institutional Review Board approval is not required. The authors certify that they have obtained all appropriate patient consent. There are no conflicts of interest. The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI. https://doi.org/10.25259/SNI_941_2024 The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Journal or its management. The information contained in this article should not be considered to be medical advice; patients should consult their own physicians for advice as to their specific medical needs.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/placeholders/specialty/skull-base.png","publishDate":"2025-04-11T00:00:00.000Z","doi":"10.25259/SNI_941_2024","categories":["Skull Base","Video Abstract"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/8ac8b54b-0373-4cd3-b59b-ead15fac6770/pdf"}