{"id":"741db546-d1a2-4fb6-9bff-e7a88d0029d5","slug":"eosinophilic-granulomalangerhans-cell-histiocytosis-pediatric-neurosurgery-update","title":"Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update","authors":["Sandi Lam","Gaddum D. Reddy","Rory Mayer","Yimo Lin","Andrew Jea"],"abstract":"Background: Langerhans cell histiocytosis (LCH) is a rare, heterogeneous disease characterized by the proliferation of dendritic cells. It encompasses a spectrum of conditions, from localized lesions to diffuse multiorgan involvement, with eosinophilic granuloma (EG) being the most common subtype affecting the bone. LCH primarily affects children and can involve various organ systems, including the skeletal system, skin, and endocrine organs. Methods: This article presents two illustrative cases of pediatric patients diagnosed with LCH, detailing their clinical presentations, imaging findings, surgical interventions, and subsequent treatments. Case 1 involved a 23-month-old female with a cervical spine lesion, while Case 2 involved a 17-year-old male with a scalp mass. Both cases underwent surgical resection followed by outpatient chemotherapy. Results: In Case 1, the 23-month-old female underwent a C2 to C5 laminectomy with partial resection of the lesion, which was confirmed to be LCH through pathology. The patient was discharged after surgery and started outpatient chemotherapy with cytarabine. In Case 2, the 17-year-old male had a gross total resection of the scalp lesion, also confirmed as LCH, and was discharged the following day, subsequently starting outpatient chemotherapy. Conclusion: LCH presents unique challenges in pediatric neurosurgery due to its variable clinical manifestations and treatment responses. Surgical intervention remains a critical component of management, particularly in cases with neurological compromise or significant mass effect. Further research is necessary to establish standardized treatment protocols and improve outcomes for affected children. Keywords: Langerhans cell histiocytosis, eosinophilic granuloma, pediatric neurosurgery, surgery, chemotherapy, case report","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/741db546-d1a2-4fb6-9bff-e7a88d0029d5/featured/hero-1782420959118.png","publishDate":"2015-10-07T00:00:00.000Z","doi":"10.4103/2152-7806.166761","categories":["Pediatric Neurosurgery","Original Article"],"fullTextUrl":"http://surgicalneurologyint.com/wp-content/uploads/2015/10/6294/SNI-6-435.pdf"}