{"id":"7ecec582-7dc6-48ad-9a6b-cd7b4812aa5e","slug":"extradural-malignant-peripheral-nerve-sheath-tumor-of-the-thoracic-spine-a-rare-case-report","title":"Extradural malignant peripheral nerve sheath tumor of the thoracic spine: A rare case report","authors":["Ayu Yoniko Christi","Wisnu Baskoro","Bidari Kameswari","Irfaanstio Akbar Hakim","Vega Sola Gracia Pangaribuan","Andrianto Purnawan"],"abstract":"Background: Malignant peripheral nerve sheath tumors (MPNSTs) typically found in the trunk, limbs, head, and neck represent 3–10% of all soft-tissue sarcomas. Although they typically originating from peripheral nerve Schwann cells, 2–3% arise from the spinal nerves and may be found within the spinal canal. Here, we present a 43-year-old male with an extradural thoracic MPNST contributing to marked cord compression and a progressive paraparesis. Case Description: A 43-year-old male presented with a progressive paraparesis of 16 months’ duration. The MRI showed a posterior T2-T4 extradural tumor in the thoracic spine resulting in significant cord compression. Following a T2-T4 laminectomy and gross total excision of the epidural mass, the patient regained modest neurological function. Immunohistochemistry staining supported the diagnosis of thoracic spinal MPNST. Conclusion: Rarely, spinal MPNST can be considered amongst the differential diagnoses of an extradural spinal tumor. In this case, gross total excision of a posterior T2-T4 epidural MPNST resulted in improvement in the patient’s original paraparesis. Notably, immunohistochemistry staining helped confirm the diagnosis of a MPNST.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/7ecec582-7dc6-48ad-9a6b-cd7b4812aa5e/featured/hero-1781561845145.png","publishDate":"2021-11-16T00:00:00.000Z","doi":"10.25259/SNI_1055_2021","categories":["Spine","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2021/11/11229/SNI-12-560.pdf"}