{"id":"fd79d7fd-a816-4ce4-941b-7c74ab856d6c","slug":"from-the-bench-to-the-bedside-spinal-cord-regeneration-niacin-for-stroke-magnetic-nanoparticles-stimulation-for-epilepsy-role-of-galanins-in-epilepsy-functions-of-the-supramarginal-gyri-and-the","title":"From the bench to the bedside: Spinal cord regeneration, niacin for stroke, magnetic nanoparticles, stimulation for epilepsy, role of galanins in epilepsy, functions of the supramarginal gyri, and the role of inflammation in postoperative cognitive disturbances","authors":["Jason S. Hauptman","Michael Safaee"],"abstract":"Background: The regeneration of the corticospinal tract following spinal cord injury holds significant potential for restoring volitional movement. However, adult corticospinal neurons exhibit resistance to regrowth techniques. This study investigates the role of Pten, a regulatory enzyme influencing mTOR activity, in promoting axonal sprouting after injury. Methods: The authors conducted experiments involving the deletion of Pten to assess its impact on mTOR activity and axon sprouting in corticospinal neurons following spinal cord crush lesions. Additionally, they explored the effects of niacin on neuronal recovery post-stroke and the application of magnetic nanoparticles for targeted drug delivery in brain tumors. Results: Findings indicated that Pten deletion led to increased mTOR activity and substantial axon sprouting from corticospinal neurons. Niacin treatment resulted in enhanced markers for axons and synapses in stroke-affected brain tissue, alongside increased BDNF and TrkB levels. The use of magnetic nanoparticles demonstrated effective targeting and drug delivery to tumor sites, resulting in reduced tumor progression. Conclusion: This research underscores the potential of manipulating Pten for enhancing neuronal regeneration, the therapeutic benefits of niacin in stroke recovery, and the promising application of magnetic nanoparticles for targeted brain tumor treatment. Future studies are warranted to translate these findings into clinical practice. Keywords: spinal cord injury, Pten, niacin, stroke, magnetic nanoparticles, brain tumors, epilepsy, galanin","thumbnailUrl":null,"publishDate":"2010-10-20T00:00:00.000Z","doi":"10.4103/2152-7806.71985","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2015/05/5921/SNI-1-66.pdf"}