{"id":"6d5a53ac-8689-4623-afb0-d27a722a755e","slug":"giant-malignant-peripheral-nerve-sheath-tumor-illustrative-case-and-surgical-technique","title":"Giant malignant peripheral nerve sheath tumor: Illustrative case and surgical technique","authors":["Jorge L Olivares Peña","Jorge A Santos Franco","Jorge L Olivares Camacho","Fiacro Jimenez-Ponce","Hector R Lara Torres","Zulma Cuevas Beltrán"],"abstract":"Background: Malignant peripheral nerve sheath tumors (MPNSTs) are one of the most difficult malignant mesenchymal neoplasms to treat. They can arise from a preexisting peripheral nerve sheath or in neurofibromatosis type 1 (NF1) patients. MPNSTs in the head-and-neck region represent approximately 2–6% of all head-and-neck sarcomas and account for 12–19% of all MPNSTs. It has an incidence of 0.001% in the general population, and prognosis is typically poor; only between 20% and 50% of patients survive 5 years after diagnosis. The complete surgical resection is recommended whenever possible. Case Description: The authors report the case of a 31-year-old woman with a history of plexiform neurofibroma, who presented with recurrence with disease progression to MPNST, without association with NF1 disease. The aim of tumor resection is symptomatic relief. Conclusion: These tumors have a high risk of severe complications and even mortality due to various causes. The benefits – including the emotional ones – can be so significant that, despite their malignant lineage, resection and regrowth control remain worthwhile for as long as possible. Four- or six-hand surgery for these tumors can reduce bleeding, operative time, and complications.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/6d5a53ac-8689-4623-afb0-d27a722a755e/featured/hero-1781557861559.png","publishDate":"2026-02-20T00:00:00.000Z","doi":"10.25259/SNI_685_2025","categories":["Neuro-oncology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2026/02/14333/SNI-17-97.pdf"}