{"id":"cb7dfedd-1330-427c-a643-c77f15770ff8","slug":"glial-fibrillary-acidic-protein-immunopositive-neuroglial-tissues-with-or-without-ependyma-lined-canal-in-spinal-lipoma-of-filar-type-relationship-with-retained-medullary-cord","title":"Glial fibrillary acidic protein immunopositive neuroglial tissues with or without ependyma-lined canal in spinal lipoma of filar type: Relationship with retained medullary cord","authors":["Nobuya Murakami","Takato Morioka","Ai Kurogi","Satoshi O. Suzuki","Takafumi Shimogawa","Nobutaka Mukae","Koji Yoshimoto"],"abstract":"Background: Retained medullary cord (RMC) and filar lipomas are believed to originate from secondary neurulation failure; filar lipomas are reported to histopathologically contain a central canal-like ependyma-lined lumen with surrounding neuroglial tissue with ependyma-lined central canal (NGT w/E-LC) as a remnant of the medullary cord, which is a characteristic histopathology of RMC. With the addition of glial fibrillary acidic protein (GFAP) immunostaining, we reported the presence of GFAP-positive NGT without E-LCs (NGT w/o E-LCs) in RMC and filar lipomas, and we believe that both have the same embryopathological significance. Methods: We examined the frequency of GFAP-positive NGT, with or without E-LC, in 91 patients with filar lipoma. Results: Eight patients (8.8%) had NGT w/E-LC, 25 patients (27.5%) had NGT w/o E-LC, and 18 patients (19.8%) had tiny NGT w/o E-LC that could only be identified by GFAP immunostaining. Combining these subgroups, 56% of the patients (n = 51) with filar lipoma had GFAP immunopositive NGT. Conclusion: The fact that more than half of filar lipomas have NGT provides further evidence that filar lipoma and RMC can be considered consequences of a continuum of regression failure that occurs during late secondary neurulation.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/cb7dfedd-1330-427c-a643-c77f15770ff8/featured/hero-1781559233381.png","publishDate":"2024-09-13T00:00:00.000Z","doi":"10.25259/SNI_458_2024","categories":["Pediatric Neurosurgery","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2024/09/13098/SNI-15-326.pdf"}