{"id":"5a1afd56-adc7-4424-a214-f57db1f0a25c","slug":"gross-total-resection-do-we-want-survival-statistics-or-quality-of-life-measurements","title":"Gross total resection: Do we want survival statistics or quality of life measurements","authors":["James I. Ausman"],"abstract":"Aim: To explore how grip strength is related to functional status and health-related quality of life (HRQoL) in amyotrophic lateral sclerosis (ALS) patients. Methods: In the phase 2 trial of TBN for treatment of ALS, 148 patients in full analysis set received TBN (600 mg or 1200 mg) or a placebo for 180 days. Outcome measurements included ALS Functional Rating Scale-Revised (ALSFRS-R), 40-item ALS Assessment Questionnaire (ALSAQ-40), grip strength, and forced vital capacity (FVC). Spearman's rank correlation was used to examine associations between grip strength, ALSFRS-R and ALSAQ-40. A principal component analysis-ANCOVA model adjusted for sex was used to further explore the associations. Results: Grip strength was strongly correlated with ALSFRS-R fine motor function domain (r s = 0.740) and moderately correlated with ALSAQ-40 activities of daily living (ADL) domain (r s = -0.637) (p < 0.05). Weak correlations were observed between FVC and both ALSFRS-R total score (r s = 0.355) and respiratory domain (r s = 0.229) and ALSAQ-40 domains. Grip strength was a strong predictor of ALSFRS-R fine motor and ALSAQ-40 ADL domains. Conclusion: Grip strength was associated with functional status and HRQoL, supporting its potential role as a meaningful clinical outcome measure in patients with ALS.","thumbnailUrl":null,"publishDate":"2014-05-26T00:00:00.000Z","doi":"10.4103/2152-7806.133200","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/5a1afd56-adc7-4424-a214-f57db1f0a25c/pdf"}