{"id":"70cb3c14-2d95-4c5a-8957-79cfe07e17ae","slug":"hitting-all-the-right-markers-to-save-a-life-solitary-fibrous-tumors-of-the-central-nervous-system-case-series-and-review-of-the-literature","title":"“Hitting all the right markers to save a life” Solitary fibrous tumors of the central nervous system: Case series and review of the literature","authors":["Ekkehard Kasper","Scott Boruchow","Fred C. Lam","Pascal O. Zinn","Matthew Anderson","Anand Mahadevan"],"abstract":"Background: Solitary fibrous tumors (SFTs) are rare spindle cell tumors of mesenchymal origin, primarily known from the mediastinum and visceral pleura. While over 800 cases of pleural SFTs have been documented, SFTs in the central nervous system (CNS) are exceedingly rare, with fewer than 100 reported cases. These tumors are often dura-based and can occur in various locations within the CNS, presenting unique clinicopathological challenges. Methods: This study presents two cases of large SFTs, detailing their imaging, histological findings, and clinical management. The first case involved a 65-year-old male with a left parietooccipital lesion, while the second case featured a 70-year-old female with a right parietal convexity lesion. Both cases were managed surgically, and histopathological analyses were conducted to confirm the diagnosis. Results: In the first case, a gross total resection was achieved, and the patient remained seizure-free with no evidence of disease recurrence at 30 months post-surgery. The second case involved a malignant transformation of the tumor after initial radiotherapy, leading to multiple resections and eventual recurrence, highlighting the aggressive nature of SFTs. Conclusion: SFTs of the CNS present significant diagnostic and therapeutic challenges due to their rarity and potential for aggressive behavior. The extent of resection appears to be a critical prognostic factor, and awareness of this tumor entity is essential for neurosurgeons to optimize patient outcomes. Keywords: solitary fibrous tumor, CNS, neurosurgery, case series, histopathology, malignant transformation, surgical management","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/70cb3c14-2d95-4c5a-8957-79cfe07e17ae/featured/hero-1782421037753.png","publishDate":"2012-07-28T00:00:00.000Z","doi":"10.4103/2152-7806.99173","categories":["Original Article"],"fullTextUrl":"http://sni.wpengine.com/wp-content/uploads/2015/05/3407/SNI-3-83.pdf"}