{"id":"66d7f5fc-ba56-4765-9201-134a32716311","slug":"ileal-signet-ring-cell-carcinoma-with-brain-metastases-a-case-report","title":"Ileal signet-ring cell carcinoma with brain metastases: A case report","authors":["Jorge Cabrera-Montes","Daniela Fuel-Gómez","Monica Lara-Almunia"],"abstract":"Background: Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that frequently originates in the stomach. Uncommonly, this tumor can lead to brain metastases; an event rarely reported in the literature. Case Description: A 76-year-old man with a history of cognitive impairment was diagnosed with two brain space-occupying lesions. A whole-body 18F-FDG PET/computed tomography scan revealed a hypermetabolic lesion in a segment of the ileum corresponding to mural thickening and an ulcerated lesion detected on colonoscopy. A brain biopsy, using an immunohistochemistry protocol, showed signet-ring cells with a pattern that suggested an intestinal origin. The diagnosis of SRCC brain metastases with an ileal origin was made, and a treatment protocol was designed. However, the patient rapidly deteriorated, and passed away shortly afterward. Conclusion: To the best of our knowledge, this is the first case report of an ileal SRCC with brain metastases.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/66d7f5fc-ba56-4765-9201-134a32716311/featured/hero-1781560608889.png","publishDate":"2023-01-06T00:00:00.000Z","doi":"10.25259/SNI_870_2022","categories":["Neuro-oncology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2023/01/12093/SNI-14-6.pdf"}