{"id":"296d233c-2adb-4e4f-93a8-74a6887711c6","slug":"impact-of-local-treatment-on-survival-from-hematological-malignancies-causing-spinal-cord-compression","title":"Impact of local treatment on survival from hematological malignancies causing spinal cord compression","authors":["Hela Ghedira","Khaled Radhouane","Essia Mezni","Safia Yahiaoui","Hela Stambouli","Mohamed Dehmani Yedeas","Asma Belaid","Chiraz Ammar","Karima Kacem","Samy Zriba","Fehmi Msadek","Mondher Yedeas","Ahmed Harbaoui","Ridha Chkili"],"abstract":"Background: Various hematological malignancies, including multiple myeloma, plasmacytoma, aggressive lymphoma, and indolent lymphoma, rarely result in spinal cord compression. Methods: Here, we retrospectively analyzed 32 patients with multiple myeloma (50%), plasmacytoma (13%), aggressive lymphoma (28%), and indolent lymphoma (9%), resulting in spinal cord compression (2004 and 2016). Patients averaged 57 years of age and presented with the indolent onset of spinal cord compression (91% of cases) resulting mostly in motor deficits (69%). Results: Local treatment modalities included radiotherapy (RT) (28%) alone, decompressive surgery (28%) alone, or decompressive surgery with consolidation RT (40%). The 1-year overall survival was 70%, and the progression-free survival frequency was 62%. Conclusion: This study highlighted the importance of standardizing the indications for RT alone versus RT with surgery depending on the patient’s underlying pathological diagnosis, neurological deficits, and radiological findings.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/296d233c-2adb-4e4f-93a8-74a6887711c6/featured/hero-1781563050082.png","publishDate":"2020-10-21T00:00:00.000Z","doi":"10.25259/SNI_592_2020","categories":["Spine","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/296d233c-2adb-4e4f-93a8-74a6887711c6/pdf"}