{"id":"e483400e-8c2d-4315-a94a-566def7db4a5","slug":"intracranial-fungal-mass-imitating-a-high-grade-glial-lesion-is-antifungal-alone-sufficient","title":"Intracranial fungal mass imitating a high-grade glial lesion – is antifungal alone sufficient?","authors":["Warda Ahmed","Syed Ather Enam","Hafiza Fatima Aziz"],"abstract":"Background: Intracranial fungal mass is rare among immunocompetent individuals with variable presentation and management algorithms making it challenging to achieve optimal outcomes. Case Description: Herein, we report the presentation of a 34-year-old immunocompetent Pashtun female with acute-onset rapidly progressing generalized weakness, altered cognition, and motor and speech deficits. Although the radiological findings resembled a glioblastoma, the strong clinical suspicion of a fungal infection and her improvement on voriconazole treatment led to the decision to avoid surgical resection, thereby minimizing the risk of potential dissemination. Conclusion: Our case emphasizes that any deviation from the typical presentation of high-grade tumors must be reviewed with the need for surgical resection being evaluated on a case-to-case basis while prioritizing patient outcomes.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/e483400e-8c2d-4315-a94a-566def7db4a5/featured/hero-1781558447862.png","publishDate":"2025-07-18T00:00:00.000Z","doi":"10.25259/SNI_161_2025","categories":["Unique Case Observations","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2025/07/13719/SNI-16-297.pdf"}