{"id":"03cbc4cf-a65d-4f34-a2d4-084ee7b37b26","slug":"intracranial-phosphaturic-mesenchymal-tumor-mixed-connective-tissue-variant-presenting-without-oncogenic-osteomalacia","title":"Intracranial phosphaturic mesenchymal tumor, mixed connective tissue variant presenting without oncogenic osteomalacia","authors":["Regina S. Bower","Wilson P. Daugherty","Caterina Giannini","Ian F. Parney"],"abstract":"Background: Phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT) is a rare tumor typically occurring in soft tissues and bone, causing oncogenic (tumor-induced) osteomalacia (TIO) through secretion of the phosphaturic hormone, fibroblast growth factor-23 (FGF-23). Rare tumors identical to PMTMCT occur without known TIO. Intracranial localization of PMTMCT is extremely rare, with only two cases reported in the literature. We present a very unusual case of a patient with an intracranial PMTMCT that presented with neurologic changes without osteomalacia. Case Description: A 67-year-old woman presented with progressive incontinence, apathy, and abulia after having undergone a total knee replacement 1 month earlier. Imaging disclosed a large left frontal anterior fossa mass. She underwent uncomplicated surgical resection of this tumor. Surprisingly, histopathology suggested PMTMCT. Reverse transcription polymerase chain reaction (RT-PCR) assay demonstrating FGF-23 expression in the tumor confirmed the diagnosis. Serum FGF-23 levels postoperatively were normal and she had no clinical or laboratory evidence of osteomalacia or phosphaturia. Conclusion: This report should serve to alert clinicians to the possibility that PMTMCT can be included in the differential diagnosis of intracranial masses even in the absence of tumor-induced osteomalacia.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/03cbc4cf-a65d-4f34-a2d4-084ee7b37b26/featured/hero-1782420978182.png","publishDate":"2012-12-14T00:00:00.000Z","doi":"10.4103/2152-7806.104745","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/03cbc4cf-a65d-4f34-a2d4-084ee7b37b26/pdf"}