{"id":"b4bdd7cb-501f-41f3-836a-d7bc7271e6e3","slug":"letter-to-the-editor-regarding-clear-cell-renal-cell-carcinoma-and-glioblastoma-multiforme-coexistence-double-primary-malignancy-does-it-have-a-causal-relationship","title":"Letter to the Editor regarding “Clear-cell renal cell carcinoma and glioblastoma multiforme coexistence: Double primary malignancy, does it have a causal relationship?”","authors":["Andrew Leland Waack","Brandon Sharkey","Alastair Hoyt","Jason L. Schroeder"],"abstract":"Background: We recently encountered a case of metachronous renal cell carcinoma (RCC) and glioblastoma multiforme (GBM) that parallels the findings of Simanjuntak et al. Their article discusses the coexistence of these two malignancies, raising questions about potential causal relationships. Summary: The presented case involves a 61-year-old woman with a history of RCC who developed GBM four years post-nephrectomy. Despite surgical intervention, the patient experienced complications and ultimately passed away three weeks after the procedure. A review of the literature indicates that this case represents the 132nd known instance of concurrent RCC and GBM. Conclusion: There is currently no established relationship linking RCC and GBM, and their coexistence may be coincidental. Each malignancy should be treated as a separate entity according to established standards of care, and further documentation of such cases is essential to understand their true occurrence. Keywords: renal cell carcinoma, glioblastoma, double primary malignancy, metachronous, coexistence, case report, literature review","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/b4bdd7cb-501f-41f3-836a-d7bc7271e6e3/featured/hero-1781560402389.png","publishDate":"2023-04-07T00:00:00.000Z","doi":"10.25259/SNI_151_2023","categories":["Neuro-oncology","Letter to the Editor"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2023/04/12235/SNI-14-134.pdf"}