{"id":"300329c1-25d2-4881-9205-02992b630089","slug":"memory-and-executive-functioning-outcomes-of-selective-amygdalohippocampectomy-in-patients-with-hippocampal-sclerosis-a-preliminary-study-in-a-developing-country","title":"Memory and executive functioning outcomes of selective amygdalohippocampectomy in patients with hippocampal sclerosis: A preliminary study in a developing country","authors":["Seyyedeh Somayyeh Moshir Estekhareh","Sajjad Saghebdoust","Reza Zare","Mohsen Aghaee Hakak","Bahram Ali Ghanbari Hashemabadi"],"abstract":"Background: Selective amygdalohippocampectomy (SA) is an effective treatment for drug-resistant cases of epilepsy due to hippocampal sclerosis (HS). However, its neurocognitive outcomes are inconsistent across the previous studies, pointing to potential location-specific confounders. Here, we investigated the neurocognitive outcomes of SA in an Iranian center recently adopting this approach. Methods: Thirty adults (53.3% of females, age 31.4 ± 6.2 years) with drug-resistant epilepsy due to HS were included in the study. Patients were stratified into surgical (n = 15) and medical (n = 15) treatment groups based on their preferences. Neurocognitive function was assessed before and 6 months after intervention using Wisconsin Card Sorting Test (WCST), Wechsler Adult Intelligence Scale-Revised, and Wechsler Memory Scale- Third Edition (WMS-III). Postintervention performance changes were compared between the two groups, and predictors of worse postoperative outcomes were investigated. Results: Longitudinal changes of performance in WMS-III and WCST were significantly different between the surgically and medically treated patients. Postoperative WMS-III performance showed an average 25% decline (mean ∆T2-T1 = –25.1%, T = –6.6, P P P < 0.001). Conclusion: In our center, executive functioning improved or remained stable after SA, but memory functions declined moderately. The left-sided SA and higher education were associated with more severe decline in memory functions, highlighting the need for special considerations for these groups.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/300329c1-25d2-4881-9205-02992b630089/featured/hero-1781561423653.png","publishDate":"2022-04-22T00:00:00.000Z","doi":"10.25259/SNI_49_2022","categories":["Epilepsy","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/04/11554/SNI-13-161.pdf"}