{"id":"6e483bc3-268c-4185-b8df-862f848c8058","slug":"mtor-activation-is-increased-in-pilocytic-astrocytomas-from-older-adults-compared-with-children","title":"mTOR activation is increased in pilocytic astrocytomas from older adults compared with children","authors":["Mahlon D. Johnson","Mary O’Connell","Kevin Walter","Howard Silberstein"],"abstract":"Background: Recent studies suggest that the behavior and biology of WHO grade I pilocytic astrocytomas (PAs) in adults is different than that associated with grade I PAs in children. Methods: We evaluated Ki-67 labeling, BRAF abnormalities, isocitrate dehydrogenase R132 immunoreactivity phosphorylation (activation) of p44/42 mitogen activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) in formalin-fixed tissue from 21 adult (18 years or older, mean age 37 years) and 10 children (mean age 9.4 years) WHO grade I PAs. Results: The mean Ki-67 labeling was 4.8% in adults and 3.8% in children. There was no significant difference between Ki-67 labeling in children and adults or either subgroups of adults. No differences were found in phospho p44/42MAPK in adult subgroups (18–33 years and 34 and older) compared to children. Activation/phosphorylation of mTOR was biphasic in adults being significantly lower than children in young adults but significantly higher than children in older adults (age 34 and older). Conclusions: Identifying mTOR phosphorylation/activation may represent a difference in biology and a new marker to guide chemotherapy with recently approved mTOR inhibitors.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/6e483bc3-268c-4185-b8df-862f848c8058/featured/hero-1782420813058.png","publishDate":"2017-05-26T00:00:00.000Z","doi":"10.4103/sni.sni_367_16","categories":["Pediatric Neurosurgery","Original Article"],"fullTextUrl":"http://surgicalneurologyint.com/wp-content/uploads/2017/06/8403/SNI-8-85.pdf"}