{"id":"ddbf9342-40e9-429e-8b02-330ac69268fa","slug":"pineal-region-ganglioglioma-a-neoplasm-with-a-bimodal-age-distribution","title":"Pineal region ganglioglioma: A neoplasm with a bimodal age distribution","authors":["Osama A. Al-Dalahmah","Linda Wang","Susan J. Hsiao","Chun-Chieh Lin","Mahesh M. Mansukhani","Peter Canoll","Jeffrey N. Bruce","George Zanazzi"],"abstract":"Background: Gangliogliomas arise very rarely in the pineal region, where their natural histories and pathologic features are poorly understood. Case Description: In this report, we describe a 36-year-old woman who presented with a seizure followed by worsening headache, dizziness, confusion, and intermittent left facial numbness over the next few weeks. A head CT scan showed a partially calcified pineal region mass with hydrocephalus. After an endoscopic third ventriculostomy, the patient underwent a resection of the tumor that contained dysplastic ganglion cells and piloid glial cells. Molecular profiling of this CNS WHO Grade 1 ganglioglioma revealed polysomies of chromosomes 7 and 9, and a BUB1 variant of uncertain significance, without known MAP kinase pathway alterations. From a review of the literature, we found two distinct age distributions for pineal ganglioglioma, with modes at 1 and 36 years of age. Conclusion: Although very rare, this tumor should be considered in the differential diagnosis of pineal region tumors in children and young adults.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/ddbf9342-40e9-429e-8b02-330ac69268fa/featured/hero-1781561278336.png","publishDate":"2022-06-10T00:00:00.000Z","doi":"10.25259/SNI_443_2022","categories":["Neuropathology","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/ddbf9342-40e9-429e-8b02-330ac69268fa/pdf"}