{"id":"dd4d576e-07fe-4dba-8cb5-c6310665f8b6","slug":"prevalence-of-unruptured-intracranial-aneurysms-among-first-degree-relatives-of-thai-patients-who-had-aneurysmal-subarachnoid-hemorrhage","title":"Prevalence of unruptured intracranial aneurysms among first-degree relatives of Thai patients who had aneurysmal subarachnoid hemorrhage","authors":["Waneerat Galassi","Warin Yuyangkate","Paweena Paholthep","Thipsumon Tangsriwong","Ponnarong Jaikon","Thongchai Leiwan","Jiroje Jiranukool","Peeraphong Thiarawat"],"abstract":"Background: The prevalence of familial unruptured intracranial aneurysm (UIA) in Thai population was unknown. Methods: Our study population comprised first-degree relatives of patients who were diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) in two cerebrovascular neurosurgical centers from January 2018 to December 2018. The volunteers underwent three-dimensional time-of-flight magnetic resonance angiography for screening intracranial aneurysms (IA). Those who were reported positive or suspected of IA then underwent computed tomography angiography for confirmation. Results: We identified 12 patients who had 12 unruptured IAs (UIAs) from among 93 first-degree relatives. The prevalence of UIA among our study population was 12.9%. An estimated prevalence of UIA among Thai population was 9.05% (95% confidence interval [CI] 7.32–10.78). Of the 93 relatives, 84 had only one first-degree relative who suffered aSAH. Siblings posed a higher risk for UIA than offspring (16% vs. 9.5%), but the difference was not statistically significant (odds ratio 1.810, 95% CI 0.50–6.50, P = 0.274). The most common aneurysm location was the anterior cerebral artery territory (50%). Conclusion: The prevalence of familial UIA in a Thai population was relatively high. There was no significant between-group difference in the occurrence of UIA between the siblings and offspring of the aSAH patients.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/dd4d576e-07fe-4dba-8cb5-c6310665f8b6/featured/hero-1781561815047.png","publishDate":"2021-11-23T00:00:00.000Z","doi":"10.25259/SNI_741_2021","categories":["Neurovascular","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2021/11/11249/SNI-12-566.pdf"}