{"id":"732f1e88-5706-409c-845d-5504f24cd7e6","slug":"primary-anaplastic-lymphoma-kinase-negative-anaplastic-large-cell-lymphoma-of-cervical-spine-presenting-with-quadriplegia-a-case-report-and-literature-review","title":"Primary anaplastic lymphoma kinase-negative anaplastic large cell lymphoma of cervical spine presenting with quadriplegia: A case report and literature review","authors":["Garga Basu","Michael L. Anthony","Anamika Bakliwal","Debranjani Chattopadhyay","Prashant P. Joshi","Rajnish Kumar Arora","Radhey Shyam Mittal","Uttam Kumar Nath"],"abstract":"Background: An anaplastic large cell lymphoma (ALCL) involving the cervical spine and leading to quadriplegia is very rare. Case Description: A 48-year-old immunocompetent male presented with quadriplegia that warranted an anterior cervical corpectomy/fusion. He was previously being presumptively treated for cervical disease attributed to tuberculosis. The histopathology and immunohistochemistry revealed an ALCL that was anaplastic lymphoma kinase (ALK) negative. The patient had a favorable response to surgery followed by CHOEP (cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisolone) chemotherapy. Conclusion: ALK-negative ALCL presenting with quadriplegia due to primary involvement of cervical spine is extremely rare, but must be diagnosed and appropriately managed.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/732f1e88-5706-409c-845d-5504f24cd7e6/featured/hero-1781563002806.png","publishDate":"2020-11-06T00:00:00.000Z","doi":"10.25259/SNI_634_2020","categories":["Spine","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/732f1e88-5706-409c-845d-5504f24cd7e6/pdf"}