{"id":"04fac705-5066-4ac8-a273-00499c4662e3","slug":"prognostic-factors-following-resection-of-intracranial-metastases","title":"Prognostic factors following resection of intracranial metastases","authors":["Duncan Henderson","Arif Zafar","Anna Bjornson","Adam Razak","Shailendra Achawal","Mihai Danciut","Aubrey Smith","Gerry O’Reilly","Chittoor Rajaraman","Anuj Bahl"],"abstract":"Background: The aim of this study was to identify prognostic factors associated with resection of intracranial metastases. Methods: A retrospective case series including patients who underwent resection of cranial metastases from March 2014 to April 2021 at a single center. This identified 112 patients who underwent 124 resections. The median age was 65 years old (24–84) and the most frequent primary cancers were nonsmall cell lung cancer (56%), breast adenocarcinoma (13%), melanoma (6%), and colorectal adenocarcinoma (6%). Postoperative MRI with contrast was performed within 48 hours in 56% of patients and radiation treatment was administered in 41%. GraphPad Prism 9.2.0 was used for the survival analysis. Results: At the time of data collection, 23% were still alive with a median follow-up of 1070 days (68–2484). The 30- and 90-day, and 1- and 5-year overall survival rates were 93%, 83%, 35%, and 17%, respectively. The most common causes of death within 90 days were as follows: unknown (32%), systemic or intracranial disease progression (26%), and pneumonia (21%). Age and extent of neurosurgical resection were associated with overall survival (P 70 had a median survival of 5.4 months compared with 9.7, 11.4, and 11.4 for patients <50, 50–59, and 60–69, respectively. Gross-total resection achieved an overall survival of 11.8 months whereas sub-total, debulking, and unclear extent of resection led to a median survival of 5.7, 7.0, and 9.0 months, respectively. Conclusion: Age and extent of resection are potential predictors of long-term survival.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/04fac705-5066-4ac8-a273-00499c4662e3/featured/hero-1781561311144.png","publishDate":"2022-05-27T00:00:00.000Z","doi":"10.25259/SNI_103_2022","categories":["Neuro-oncology","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/05/11624/SNI-13-219.pdf"}