{"id":"70570720-f178-4258-8e26-f9ee532df8ba","slug":"prognostic-factors-in-brain-metastases-from-laryngeal-squamous-cell-carcinoma-case-report-and-review","title":"Prognostic factors in brain metastases from laryngeal squamous cell carcinoma: Case report and review","authors":["Nicola Montano","Alessandro Rapisarda","Fabrizio Pignotti","Marco Gessi"],"abstract":"Background: Brain metastases from laryngeal squamous cell carcinoma (SCC) are rare, and there are no standardized treatments. Here we reported on a case of brain metastasis from laryngeal SCC and performed a literature review on these cases. Moreover, by plotting Kaplan–Meier curves, we carried out a survival analysis to provide an estimation of overall survival (OS) and to find possible prognostic factors. Case Description: A 65-year-old male was admitted to our department with a large left occipital lesion. Three years ago, the patient had undergone total laryngectomy with bilateral neck dissection with a diagnosis of a poor differentiated SCC. The occipital lesion was totally removed. A diagnosis of a brain metastasis from laryngeal SCC was made. The patient was submitted to adjuvant chemotherapy and radiation therapy. He is in good clinical conditions at 7-month follow-up with a still ongoing chemotherapy. From survival analysis, we have found that surgery and/or radiochemotherapy increase the OS of these patients compared with untreated cases. Moreover, Karnofsky performance status (KPS) score ≥70 and recursive partitioning analysis (RPA) classes I and II were associated with better OS in these patients. Conclusion: Brain metastases from laryngeal SCC are rare. This is the first study in which a survival analysis of these cases has been performed. Surgery and/or radio-chemotherapy increase the survival of these patients compared with untreated cases. Moreover, KPS score and RPA class affect the outcome of these patients.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/70570720-f178-4258-8e26-f9ee532df8ba/featured/hero-1782420867075.png","publishDate":"2018-09-04T00:00:00.000Z","doi":"10.4103/sni.sni_141_18","categories":["Unique Case Observations","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/70570720-f178-4258-8e26-f9ee532df8ba/pdf"}