{"id":"5df75830-a86f-4680-a99d-908fc3c6e8e9","slug":"sni-case-of-the-week-initial-concomitant-use-of-gabapentin-clonidine-and-prednisone-may-enhance-suicidal-ideation-a-case-report","title":"SNI case of the week: Initial concomitant use of gabapentin, clonidine, and prednisone may enhance suicidal ideation: A case report","authors":["Ramsis F. Ghaly","Ana Plesca","Kenneth D. Candido","Nebojsa Nick Knezevic"],"abstract":"Background: Suicide cases are the end product of a combination of biological, clinical, psychological, social, and cultural risk/protective factors, and attempts to remain unpredictable. Case Description: A 43-year-old male presented to the hospital with jaundiced skin/eyes of 7 days’ duration. He had a history of a major depressive disorder and chronic alcohol consumption (e.g., 3–5 alcoholic drinks/day for the past 15 years). Studies documented acute hepatic disease (e.g., biopsy-documented hepatocellular alcoholic hepatitis), accompanied by a cholestatic disease. The patient was discharged on clonidine, iron multivitamin, folic acid, gabapentin, and prednisone. Eight days postdischarge from the hospital, he committed suicide (e.g., self- inflicted gunshot wound to the head). Conclusion: Concomitant administration of gabapentin, prednisone, and clonidine, especially if used for the first time, may play a synergistic effect in increasing a patient’s suicide risk.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/5df75830-a86f-4680-a99d-908fc3c6e8e9/featured/hero-1781563574774.png","publishDate":"2020-03-06T00:00:00.000Z","doi":"10.25259/SNI_58_2020","categories":["Unique Case Observations","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2020/03/9889/SNI-11-41.pdf"}