{"id":"da46a98d-603b-4b26-9c59-ba649b723b9a","slug":"stuck-at-the-bench-potential-natural-neuroprotective-compounds-for-concussion","title":"Stuck at the bench: Potential natural neuroprotective compounds for concussion","authors":["Anthony L. Petraglia","Ethan A. Winkler","Julian E. Bailes"],"abstract":"Background: While numerous laboratory studies have searched for neuroprotective treatment approaches to traumatic brain injury, no therapies have successfully translated from the bench to the bedside. Concussion is a unique form of brain injury, in that the current mainstay of treatment focuses on both physical and cognitive rest. Treatments for concussion are lacking. The concept of neuro-prophylactic compounds or supplements is also an intriguing one, especially as we are learning more about the relationship of numerous sub-concussive blows and/or repetitive concussive impacts and the development of chronic neurodegenerative disease. The use of dietary supplements and herbal remedies has become more common place. Methods: A literature search was conducted with the objective of identifying and reviewing the pre-clinical and clinical studies investigating the neuroprotective properties of a few of the more widely known compounds and supplements. Results: There are an abundance of pre-clinical studies demonstrating the neuroprotective properties of a variety of these compounds and we review some of those here. While there are an increasing number of well-designed studies investigating the therapeutic potential of these nutraceutical preparations, the clinical evidence is still fairly thin. Conclusion: There are encouraging results from laboratory studies demonstrating the multi-mechanistic neuroprotective properties of many naturally occurring compounds. Similarly, there are some intriguing clinical observational studies that potentially suggest both acute and chronic neuroprotective effects. Thus, there is a need for future trials exploring the potential therapeutic benefits of these compounds in the treatment of traumatic brain injury, particularly concussion.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/da46a98d-603b-4b26-9c59-ba649b723b9a/featured/hero-1782420835674.png","publishDate":"2011-10-12T00:00:00.000Z","doi":"10.4103/2152-7806.85987","categories":["Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2015/05/3654/SNI-2-146.pdf"}