{"id":"3cbe35f0-cdc0-4205-a462-f1465a24e2a5","slug":"study-of-certain-easily-available-biochemical-markers-in-prognostication-in-severe-traumatic-brain-injury-requiring-surgery","title":"Study of certain easily available biochemical markers in prognostication in severe traumatic brain injury requiring surgery","authors":["Ryosuke Tsuchiya","Hidetoshi Ooigawa","Tatsuki Kimura","Shinya Tabata","Takuma Maeda","Hiroki Sato","Kaima Suzuki","Yasuhiro Ohara","Yoshitaka Ooya","Manabu Nemoto","Hiroki Kurita"],"abstract":"Background: This study aimed to identify easily available prognostic factors in severe traumatic brain injury (TBI) patients undergoing craniotomy. Methods: We retrospectively analyzed the clinical characteristics (age, sex, Glasgow coma scale score, cause of TBI, and oral antithrombotic drug use), laboratory parameters (hemoglobin, sodium, C-reactive protein, D-dimer, activated partial thromboplastin time, prothrombin time-international normalized ratio, and glucose-potassium [GP] ratio), and neuroradiological findings of 132 patients who underwent craniotomy for severe TBI in our hospital between January 2015 and December 2021. The patients were divided into two groups: Those with fatal clinical outcomes and those with non-fatal clinical outcomes, and compared between the two groups. Results: The patients comprised 79 (59.8%) male and 53 (40.2%) female patients. Their mean age was 67 ± 17 years (range, 16–94 years). Computed tomography revealed acute subdural hematoma in 108 (81.8%) patients, acute epidural hematoma in 31 (23.5%), traumatic brain contusion in 39 (29.5%), and traumatic subarachnoid hemorrhage in 62 (47.0%). All 132 patients underwent craniotomy, and 41 eventually died. There were significant differences in the D-dimer, GP ratio, and optic nerve sheath diameter between the groups (all P P P 42 was the optimal cutoff value for the prediction of a fatal outcome of TBI (sensitivity, 85.4%; specificity, 51.1%). Conclusion: The GP ratio and D-dimer were significantly associated with poor outcomes of TBI. A GP ratio of >42 could be a predictor of a fatal outcome of TBI.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/3cbe35f0-cdc0-4205-a462-f1465a24e2a5/featured/hero-1781559887727.png","publishDate":"2023-12-01T00:00:00.000Z","doi":"10.25259/SNI_544_2023","categories":["Trauma","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2023/12/12655/SNI-14-410.pdf"}