{"id":"ee926789-87cb-4239-b3ed-18a3478c8dd5","slug":"successful-intravenous-alteplase-for-acute-ischemic-stroke-secondary-to-radiation-induced-intracrani","title":"Successful intravenous alteplase for acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis in a child: An illustrative case","authors":["Takahito Mitsui","Toru Kurokawa","Kohei Suzuki","Junkoh Yamamoto","Yuko Tanaka"],"abstract":"Background: Delayed cerebrovascular complications after radiotherapy have been well-documented. However, optimal management of acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis remains unclear. Case Description: A 17-year-old girl developed an acute ischemic stroke secondary to delayed middle cerebral artery stenosis following radiotherapy for recurrent craniopharyngioma after tumor resection. Intravenous alteplase (rt-PA) was administered 4 h after symptom onset, resulting in neurological improvement, and she was discharged with a modified Rankin Scale score of 0. Conclusion: This case suggests that rt-PA may be an effective treatment option for acute ischemic stroke associated with post-radiotherapy arterial stenosis, provided that the standard eligibility criteria are met.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/sni-17-366/figures/SNI-17-366-g001.jpg","publishDate":"2026-06-26T00:00:00.000Z","doi":"10.25259/SNI_389_2026","categories":["Neurovascular","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/ee926789-87cb-4239-b3ed-18a3478c8dd5/pdf"}