{"id":"37912d41-cd8a-4faf-ab0d-17262dee139d","slug":"surgical-management-of-vertebral-metastatic-gastrointestinal-stromal-tumor-case-illustration-literature-review-and-pooled-analysis","title":"Surgical management of vertebral metastatic gastrointestinal stromal tumor: Case illustration, literature review, and pooled analysis","authors":["Yu Tung Lo","David Siu Kei Mak","Colum Patrick Nolan"],"abstract":"Background: Gastrointestinal stromal tumors (GISTs) very rarely metastasize to the vertebrae. Tyrosine kinase inhibitors (TKIs) confer favorable long-term survival and durable disease control for metastatic disease. Here, we reviewed a case and the literature to determine the various management options, and neurological outcomes for these patients. Case Description: A 63-year-old Chinese female with metastatic jejunal GIST previously treated with various TKIs presented with the left lower limb weakness and a sensory level at T10. MRI revealed a T9 vertebral body tumor with cord compression. The tumor was excised and surgical fixation was performed. She received 30Gy of fractionated adjuvant radiotherapy. She achieved near-complete neurological recovery but died 2 months later from systemic disease progression. Conclusion: Based on this case and a review of the literature, surgical intervention and treatment with TKIs with adjuvant RT can lead to comparable survival and neurological outcomes.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/37912d41-cd8a-4faf-ab0d-17262dee139d/featured/hero-1781563064576.png","publishDate":"2020-10-15T00:00:00.000Z","doi":"10.25259/SNI_485_2020","categories":["Spine","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2020/10/10330/SNI-11-343.pdf"}