{"id":"8790c43c-26b1-4e7e-991a-b691988939dd","slug":"techniques-in-distal-access-of-wide-necked-giant-intracranial-aneurysms-during-treatment-with-flow-diversion","title":"Techniques in distal access of wide-necked giant intracranial aneurysms during treatment with flow diversion","authors":["Peter Kan","Ajay Kumar Wakhloo","Maxim Mokin","Ajit Puri"],"abstract":"Background: Accessing the normal distal vessel in treatment of wide-necked giant intracranial aneurysms with flow diversion can be difficult. Case Description: Through illustrative cases, the authors present several useful techniques in distal access of wide-necked giant aneurysms during flow diversion treatment. Obtaining an optimal projection that separates the outflow limb from the aneurysm is most critical. Each of the three techniques described enabled the distal access to giant intracranial aneurysms during treatment with flow diversion. Conclusion: The looped-around technique, balloon-assisted technique, and retrograde access are valuable strategies in crossing the aneurysm if direct distal access cannot be obtained. With approval from the U.S. Food and Drug Administration of the Pipeline Embolization Device (PED), the use of flow diversion has become more common for the treatment of unruptured giant aneurysms in the anterior circulation that cannot be treated by traditional endovascular methods. Early results have been very encouraging, with occlusion rates of large and giant aneurysms approaching 90% at 6 months;[ 1 ] however, the change in paradigm from an intrasaccular to an endoluminal approach has introduced a new set of technical challenges to the neurointerventionalist. In particular, access of the distal normal vessel often can be a formidable obstacle in giant aneurysms with disjointed in- and outflow limbs. Several papers have addressed the issue of maintenance of distal access once it is established,[ 2 3 5 ] but none focuses on the techniques for obtaining distal access. Through three illustrative cases, we present several techniques that are useful in crossing giant intracranial aneurysms during their treatment with flow diversion. All patients were treated with dual antiplatelets consisting of 325 mg of aspirin daily and 75 mg of clopidogrel daily for 5 days prior to the procedure. The degree of P2Y12 inhibition and aspirin response was tested with VerifyNow (Accumetrics, San Diego, CA) on the day of treatment. An aspirin response unit value of ≤550 and a Plavix Response Unit of ≤230 were considered to indicate an appropriate level of platelet inhibition for treatment. All procedures were performed under general anesthesia. Systemic heparin was used to achieve an activated clotting time of ≥250 s. To ensure robust proximal support, a triaxial system was used through femoral access in each case. This consisted of a 6 French shuttle sheath (Cook Medical, Bloomington, IN) placed in the common carotid artery prior to the bifurcation, a 5 French Navien distal access catheter (Covidien Vascular Therapies, Mansfield, MA) placed proximal to the neck of the aneurysm, and the delivery microcatheter for the flow diverter. A 73-year-old female presented with an enlarging, giant right cavernous internal carotid artery (ICA) aneurysm [ Figure 1 ]. To obtain distal access, we first found a projection that separated the distal limb from the aneurysm so that the outflow was clearly visualized. We then looped a Synchro standard 014 wire (Stryker Neurovascular, Fremont, CA) two times around the aneurysm with the stiff part of the wire in the aneurysm to increase support so that we could push the distal wire into the middle cerebral artery (MCA) [ Figure 2 ]. A SL-10 microcatheter (Stryker, Kalamazoo, MI) was then tracked into the superior MCA division. To reduce the catheter redundancy in the aneurysm, a previously described sea anchor technique was employed.[ 2 ] A Transcend 014 exchange length wire (Stryker Neurovascular, Fremont, CA) was used to exchange the microcatheter for a 4 × 40-mm Surpass device (Stryker Neurovascular, Fremont, CA). The device was deployed from the supraclinoid ICA to the posterior genu of the cavernous carotid to cover the giant aneurysm. Stasis within the aneurysm was seen immediately. The patient remained neurologically intact and was discharged on postoperative day (POD) 1. Anteroposterior (a) and lateral (b) right ICA injection revealed a giant right cavernous ICA aneurysm The looped-around technique showing a double loop of the Synchro Standard 014 microwire within the aneurysm along with its stiff part and distal access of the supraclinoid ICA A 53-year-old female presented with a 1-week loss of visual acuity over her left eye. Catheter angiography demonstrated a giant left carotid ophthalmic aneurysm [ Figure 3 ]. To obtain distal access, we again found a projection that allowed us to visualize the outflow limb independent of the aneurysm. We then shaped a Synchro standard 014 wire into a large Simmons shape to allow reentry into the distal parent vessel and access to the left MCA [ Figure 4 ]. A SL-10 microcatheter was then tracked into the MCA. To reduce the catheter redundancy in the aneurysm, the recently described stent anchor technique was used.[ 3 ] The SL-10 catheter was exchanged out for a Marksman microcatheter (Covidien, Mansfield, MA), and a 4 × 20-mm Solitaire device (Covidien) was deployed in the MCA to provide distal support and anchorage [ Figure 5 ]. Once the redundancy was reduced, the Solitaire device was recaptured, and a Synchro 014 exchange wire was used to deliver two 4 × 20-mm Surpass devices to cover the giant ophthalmic aneurysm and the additional distal cavernous aneurysm. Stasis was observed immediately in both aneurysms. The patient's vision improved, and the patient was discharged on POD2. Anteroposterior (a) and lateral (b) left ICA injection revealed a giant left carotid ophthalmic aneurysm The looped-around technique showing a Simmons-shaped Synchro Standard 014 microwire accessing the distal vessel with its reverse curve The recapturable Solitaire stent was deployed in the MCA to provide distal anchorage so that the microcatheter redundancy can be reduced without losing distal access A 58-year-old female presented with headache. A computed tomography (CT) scan did not reveal subarachnoid hemorrhage. Magnetic resonance imaging (MRI) and subsequently catheter angiography demonstrated a 3 × 2-cm giant left cavernous ICA aneurysm [ Figure 6 ]. To obtain distal access, a Hyperform 7 × 15-mm balloon (Covidien) was inflated within the aneurysm. This reduced the volume of the aneurysm to facilitate access to the distal limb of the parent vessel with the looped-around technique described above [ Figure 7 ]. The SL10 microcatheter was then exchanged for the Marksman microcatheter. Two PEDs (4.5 × 35 mm followed by a 4.5 × 20 mm) were deployed across the aneurysm with a 50% overlap. A HyperGlide 4 × 7-mm balloon was then used for angioplasty to address malapposition between the first PED and the distal vessel. Unfortunately, the two PEDs became disconnected within the aneurysm upon angioplasty, and distal access was subsequently lost. Anteroposterior (a) and lateral (b) left ICA injection revealed a giant left cavernous ICA aneurysm Anteroposterior (a) and lateral (b), a large hyperform balloon was inflated to reduce the volume of the aneurysm to facilitate crossing On a separate intervention, bilateral femoral groin access was obtained. A 5 French guide was placed in the right cervical ICA. An SL-10 microcatheter and a Synchro standard 014 wire were used to access the aneurysm retrograde across the anterior communicating artery [ Figure 8 ]. Through the right groin, our standard triaxial system was used as described above. A 6-mm snare through a Marksman microcatheter was then used to capture the Synchro microwire, and the Marksman was flossed into the distal PED/supraclinoid ICA [ Figure 9 ] as described by Hauck et al.[ 4 ] MCA access was then reestablished, and two additional PEDs (4.75 × 30 mm) were deployed to connect the disconnected devices. The patient was discharged on POD2. The 3-month and 1-year follow-up angiograms showed complete obliteration of the aneurysm. Retrograde access of the giant aneurysm across the anterior communicating artery through the distal PED Flossing technique was used to pull the Marksman microcatheter within the distal PED","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/8790c43c-26b1-4e7e-991a-b691988939dd/featured/hero-1782420888845.png","publishDate":"2015-05-28T00:00:00.000Z","doi":"10.4103/2152-7806.157797","categories":["Neurovascular","Case Report"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/8790c43c-26b1-4e7e-991a-b691988939dd/pdf"}