{"id":"3bef8414-dd12-40fb-8e3d-cf3f66345d28","slug":"the-collagen-matrix-dural-substitute-graft-prevents-postoperative-cerebrospinal-fluid-leakage-after-ventriculoperitoneal-shunt-surgery-in-patients-aged","title":"The collagen matrix dural substitute graft prevents postoperative cerebrospinal fluid leakage after ventriculoperitoneal shunt surgery in patients aged <1 year","authors":["Masanori Sato","Tatsuki Oyoshi","Hirofumi Iwamoto","Natsuko Tanoue","Soichiro Komasaku","Nayuta Higa","Hiroshi Hosoyama","Hiroshi Tokimura","Satoshi Ibara","Ryosuke Hanaya","Koji Yoshimoto"],"abstract":"Background: Cerebrospinal fluid (CSF) leakage is a common complication of ventriculoperitoneal shunt (VPS) and has the potential to induce shunt infection. Especially in infants and children, these are serious complications. DuraGen is a collagen matrix dural substitute used to reduce the risk of CSF leakage in various neurosurgeries. We report our VPS procedure with DuraGen for preventing postoperative CSF leakage in patients aged <1 year. Methods: We used DuraGen to prevent postoperative CSF leakage in six VPS surgeries. Antibiotic-impregnated shunt catheters and programmable valves with anti-siphon devices were also used in all cases. DuraGen was placed inside and atop the burr hole. All cases had an initial shunt pressure of 5 cmH2O. Fibrin glue was not used. Results: The patients underwent follow-up for a year after VPS surgery. There was no postoperative subcutaneous CSF collection or leakage after all six VPS surgeries. Furthermore, no postoperative shunt infections or DuraGen-induced adverse events were noted. Conclusion: We speculate that DuraGen has a preventive effect on postoperative CSF leakage in VPS cases aged <1 year.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/3bef8414-dd12-40fb-8e3d-cf3f66345d28/featured/hero-1781560887379.png","publishDate":"2022-10-07T00:00:00.000Z","doi":"10.25259/SNI_629_2022","categories":["Pediatric Neurosurgery","Technical Note"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/10/11917/SNI-13-461.pdf"}