{"id":"df65d4a8-c5be-4a60-8e65-ea76ae8d2868","slug":"treatment-related-complications-of-intracranial-aneurysms-smaller-than-5-mm-a-multicenter-analysis-of-1519-cases-in-latin-america","title":"Treatment-related complications of intracranial aneurysms smaller than 5 mm: A multicenter analysis of 1,519 cases in Latin America","authors":["Alejandra Jaume","Pedro Lylyk","Pablo Rubino","Jorge Mura","Daniel Mantilla","German Abdo","Carlos Bleise","Juan Mejia","Laura Campaña","Ivan Lylyk","Clara Martin","Camilo Alvarado","Matias Negrotto","Mariana Romero","Julio Quispe","Nicolas Inzunza","P. Nicolas Lylyk","Laura Olarte","Silvina Martinez","Maria Estevez","Juan Gil"],"abstract":"Background: Small (<5 mm) intracranial aneurysms present a therapeutic challenge due to their low annual rupture risk and uncertainties regarding procedure-related morbidity. Evidence from Latin America remains limited. Methods: We conducted a retrospective multicenter observational study including 1,519 patients treated between 2017 and 2023 in eight referral centers across five Latin American countries. Demographic, clinical, morphological, and treatment-related variables were analyzed. Logistic regression was used to identify independent predictors of treatment-related complications. Results: The overall complication rate was 6%. Surgical treatment showed higher crude complication rates (11%) compared with endovascular therapy (6%), largely reflecting a greater proportion of ruptured aneurysms. Independent predictors of treatment-related complications were a history of aneurysmal subarachnoid hemorrhage (odds ratio [OR] = 5.03), intraparenchymal hematoma before treatment (OR = 3.56), and ruptured aneurysm status (OR = 2.13). Complications were associated with higher mortality (31% vs. 7%; P P < 0.001). Conclusion: In this first regional multicenter series, treatment of small intracranial aneurysms in Latin America demonstrated low complication rates and favorable safety profiles for both surgical and endovascular techniques. The predictors identified may support clinical decision-making and improve prognostic assessment.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/df65d4a8-c5be-4a60-8e65-ea76ae8d2868/featured/hero-1781557874120.png","publishDate":"2026-02-20T00:00:00.000Z","doi":"10.25259/SNI_1295_2025","categories":["Neurovascular","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/df65d4a8-c5be-4a60-8e65-ea76ae8d2868/pdf"}