{"id":"dfbfc316-b1e2-4699-a2cd-627947316f06","slug":"trends-in-cognitive-dysfunction-following-surgery-for-intracranial-tumors","title":"Trends in cognitive dysfunction following surgery for intracranial tumors","authors":["Manju Dhandapani","Sandhya Gupta","Manju Mohanty","Sunil Kumar Gupta","Sivashanmugam Dhandapani"],"abstract":"Background: This study was conducted to prospectively assess the cognitive function of patients with intracranial tumors. Methods: The cognitive status of patients with intracranial tumors were prospectively studied before surgery, and later at 1 and 6 months following surgery, on purposive sampling, using validated post graduate institute (PGI) battery for brain dysfunction (score 0–30) with a higher dysfunction rating score indicating poor cognitive status. Results: Out of 23 patients enrolled, 20 could complete the study. They had substantial cognitive dysfunction before surgery (score 17.1 ± 9.4). Though there was no significant improvement (16.9 ± 9.0) at 1 month, the score improved significantly (10.3 ± 9.2) at 6 months following surgery (P = 0.008). The improvement was relatively subdued in intra-axial, malignant, and radiated tumors. Overall, there was a significant improvement in mental balance (P = 0.048), verbal retention of dissimilar pairs (P = 0.01), and recognition (P = 0.01), while dysfunction persisted in the domains of memory, verbal retention to similar pairs, and visual retention. Conclusion: Patients with intracranial tumors have substantial cognitive dysfunction, which tend to show significant improvement beyond 6 months following surgery, especially among tumors, which were extra-axial, benign, and nonirradiated.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/dfbfc316-b1e2-4699-a2cd-627947316f06/featured/hero-1782420855640.png","publishDate":"2016-03-22T00:00:00.000Z","doi":"10.4103/2152-7806.179229","categories":["General Neurosurgery","Original Article"],"fullTextUrl":"http://surgicalneurologyint.com/wp-content/uploads/2016/04/6662/SNI-7-190.pdf"}