{"id":"af50adfd-7823-4642-b580-f2c57c8c9076","slug":"understanding-gamma-ventral-capsulotomy-potential-implications-of-diffusion-tensor-image-tractography-on-target-selectivity","title":"Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity","authors":["Bruno Fernandes de Oliveira Santos","Alessandra Gorgulho","Crystian W. C. Saraiva","Antonio Carlos Lopes","João Gabriel Ribeiro Gomes","Anderson M. Pássaro","Marcelo Q. Hoexter","Eurípedes C. Miguel","Antonio A. F. De Salles"],"abstract":"Background: The role of tractography in gamma ventral capsulotomy (GVC) planning is still unclear. This paper aims to describe the spatial distribution of medial orbitofrontal cortex (OFC) and lateral OFC fibers passing through the anterior limb of the internal capsule (ALIC) and analyze quantitative tractography parameters that differentiate obsessive-compulsive disorder (OCD) individuals from other neurosurgery functional patients (morbid obesity and Parkinson’s disease [PD]). Methods: Twenty patients undergoing functional stereotactic procedures, between 2013 and 2016, were included in this study. OCD patients underwent GVC (single shot 150 Gy and 4-mm collimators). PD and morbid obesity patients were submitted to deep brain stimulation implants. Diffusion tensor image tractography was reconstructed using Brainlab Elements software (Brainlab AG, Munich, Germany). Results: Nine PD, six morbid obesity, and five OCD patients were included with a mean age of 65.4 ± 9.1, 41.0 ± 8.2, and 31.2 ± 5.5, respectively, which are statistically different from each other (P P < 0.001). Conclusions: Medial and lateral OFC tract fibers have a general standard distribution in the anterior internal capsule (lateral OFC higher than medial OFC fibers). There are differences between obesity, Parkinson, and OCD patients regarding fiber tract statistics.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/af50adfd-7823-4642-b580-f2c57c8c9076/featured/hero-1781563851062.png","publishDate":"2019-07-05T00:00:00.000Z","doi":"10.25259/SNI-65-2019","categories":["Stereotactic","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/af50adfd-7823-4642-b580-f2c57c8c9076/pdf"}