{"id":"64620193-db82-4360-826d-1f4db024a57b","slug":"vascular-endothelial-cadherin-dysfunction-a-predictor-of-hypertensive-nonlobar-intracerebral-hemorrhage","title":"Vascular endothelial cadherin dysfunction: A predictor of hypertensive nonlobar intracerebral hemorrhage","authors":["Tondi Maspian Tjili","Julius July","Eryati Darwin","Yuliarni Syafrita","Vanessa Angelica Suntoro","Patrick Putra Lukito","Jonathan Setiawan"],"abstract":"Background: Endothelial dysfunction plays a key role in intracerebral hemorrhage (ICH), with vascular endothelial cadherin (VE-cadherin) being essential for maintaining blood vessel integrity and the blood–brain barrier. Hypertension increases ICH risk by damaging blood vessel integrity due to inflammatory cascades. Lower VE-cadherin levels in hypertensive patients suggest its potential as an early predictor of ICH risk. Methods: This 12-month study included 40 hypertensive control patients and 40 hypertensive patients with nonlobar ICH. Blood samples were analyzed using enzyme-linked immunosorbent assays to measure VEcadherin, interferon gamma, and interleukin-17 levels. Receiver operating characteristic analysis determined a VE-cadherin cutoff value, and a regression model assessed its association with ICH risk. Results: A VE-cadherin cutoff value of 400.8 pg/dL was identified, with higher levels independently linked to lower odds of nonlobar ICH. VE-cadherin was the only biomarker that remained statistically significant in the regression model. These findings suggest that reduced VE-cadherin levels contribute to ICH development, and its measurement may help identify high-risk patients for early intervention. Conclusion: VE-cadherin dysfunction in hypertension may serve as a predictor of nonlobar ICH risk. Its protective role highlights its potential as a biomarker for risk assessment and prevention strategies in hypertensive patients. These findings may pave the way for targeted interventions in hypertensive populations, warranting further research to confirm its clinical utility.","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/64620193-db82-4360-826d-1f4db024a57b/featured/hero-1781558500322.png","publishDate":"2025-06-27T00:00:00.000Z","doi":"10.25259/SNI_20_2025","categories":["Neurovascular","Original Article"],"fullTextUrl":"https://surgicalneurologyint.com/api/articles/64620193-db82-4360-826d-1f4db024a57b/pdf"}