{"id":"b4ea6d8e-01c2-4caa-9676-16d6457f7884","slug":"whole-brain-transplantation-in-man-technically-feasible","title":"Whole brain transplantation in man: Technically feasible","authors":["Sergio Canavero"],"abstract":"Background: The exploration of whole brain transplantation (BT) is prompted by the lack of technologies to rejuvenate an aged body. The BRain Anastomosis Venture (BRAVE) is part of a broader project, PERSEUS, aimed at transferring an old brain into a young body to initiate brain rejuvenation. Current methodologies face significant challenges, including the extraction of the brain from the dura mater and the reconnection of cranial nerves and spinal cord. Summary: This editorial discusses the technical feasibility of whole brain transplantation, emphasizing the necessity of novel surgical techniques such as sutureless vascular anastomosis and neural fusion. The proposed method involves transplanting the brain within its dural sac to preserve vital structures and utilizing advanced technologies to facilitate rapid reconnection of blood vessels and cranial nerves. The potential for immune rejection is also addressed, particularly in the context of heterologous transplants. Conclusion: Whole brain transplantation presents a technically feasible approach, contingent upon overcoming significant surgical and immunological challenges. The integration of innovative techniques may pave the way for successful brain transfers, offering new avenues for addressing age-related cognitive decline. Further research and development are essential to refine these methodologies and assess their clinical applicability. Keywords: brain transplantation, sutureless anastomosis, neural fusion, cranial nerves, vascular reconnection, immunology, surgery, rejuvenation","thumbnailUrl":"https://sni-digital-videos.s3.amazonaws.com/articles/b4ea6d8e-01c2-4caa-9676-16d6457f7884/featured/hero-1781560642008.png","publishDate":"2022-12-23T00:00:00.000Z","doi":"10.25259/SNI_1130_2022","categories":["Spine","Editorial"],"fullTextUrl":"https://surgicalneurologyint.com/wp-content/uploads/2022/12/12068/SNI-13-594.pdf"}