- Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
- Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Ekkehard M. Kasper
Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
DOI:10.4103/2152-7806.113648Copyright: © 2013 Ohla V This is an open.access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
How to cite this article: Ohla V, Ciarlini PD, Goldsmith JD, Kasper EM. Cellular myxoma of the lumbar spine. Surg Neurol Int 19-Jun-2013;4:82
How to cite this URL: Ohla V, Ciarlini PD, Goldsmith JD, Kasper EM. Cellular myxoma of the lumbar spine. Surg Neurol Int 19-Jun-2013;4:82. Available from: http://sni.wpengine.com/surgicalint_articles/cellular-myxoma-of-the-lumbar-spine/
Background:Cellular myxoma is a histopathologically distinctive benign neoplasm, which has often been categorized among the broad category of benign mesenchymal tumors with myxoid stroma and fibroblast- and/or myofibroblast-like cells. These tumors can arise in any of the large muscles and are usually found in the thigh, shoulder, buttocks, and upper arm, and more rarely in the head and neck or in small muscles of the hand.
Case Description:Here we illustrate the case of a 57-year-old female with a spinal lesion, who initially presented with complaints of vague pelvic discomfort but no focal neurological deficits. Imaging revealed a sharply demarcated paraspinal lesion concerning for a tumorous growth. The lesion was excised in toto and a detailed immuno-histopathological analysis was performed revealing the diagnosis of a cellular myxoma. Postoperative imaging showed a gross total resection and the patient is under clinical surveillance since, with no signs of recurrence after 42 months.
Conclusion:Although very rare, this entity should be considered in the differential diagnosis of any spinal and paraspinal mass to allow for adequate treatment, which requires wide excision with clean margins to avoid any local recurrence.
Keywords: Cellular myxoma, intramuscular myxoma, lumbar myxoma, paraspinal myxoma
Among the various but scarce benign myxoid soft tissue tumors, intramuscular myxomas stand as one of the more common ones, with an incidence of 0.1 to 0.13 per 100,000.[
Typically a tumor of adulthood,[
Here, we report a 57-year-old Caucasian female, with an unremarkable past medical history, who was referred to our neurosurgical department after she presented with an incidentally found lesion on magnetic resonance imaging (MRI) of her lower spine. On physical examination the patient did complain about discomfort in her pelvic area when sitting, left greater than right. However, she did not have any related neurologic complains such as back pain or leg pain, nor did she display any weakness, numbness or tingling sensation or other signs of radiculopathy. The mass was incidentally discovered on lumbar MRI, which was obtained for evaluation of her atypical pelvic pain.
Routine MRI was obtained demonstrating a right-sided sharply demarcated, poorly and heterogeneously contrast enhancing paraspinal lesion at the junction of the lumbar and sacral spine. The mass was localized immediately adjacent to the posterior elements (lamina and spinous process) and was deeply seeded in the right multifidus muscle adjacent to the L5 inferior articular process. It measured approximately 3.0 × 3.0 × 3.5 cm in size on T1 postcontrast images
Preoperative repeat MRI was performed within a 4 week window after initial presentation and revealed an unchanged right-sided paraspinal lesion at the level of the lower posterior lumbosacral spine. The lesion measured again approximately 3.5 cm in diameter and remained heterogeneously contrast enhancing and appeared somewhat lobulated. It continued to display sharp demarcation to the surrounding soft tissue. It did not show signs of erosion or invasion of the osseous parts of the L5 posterior elements.
Surgery was performed under general anesthesia. The patient was positioned prone on a Wilson frame and a standard midline incision was performed after application of local anesthesia. The subcutaneous layers were split and the thoracolumbar fascia was divided. Dissecting into the soft tissue, we immediately identified a well encapsulated lesion deep in the paraspinal muscles, but the mass was adherent to the periostium of L5 and S1. An unremarkable dissection was performed and the lesion was resected in toto with a small soft tissue margin. Intraoperative fresh frozen analysis revealed a myxoid spindle cell tumor without significant atypia. Since the mass was abutting the osseous posterior elements of L5 and S1, we carefully coagulated the surface of the entire bony area that had been contacted to diminish the chances for any local recurrence. The wound was closed in layers and the patient had an unremarkable postoperative course. She was discharged to home the second postoperative day.
The entire specimen with a small clean margin was received for pathological examination and measured ca. 5 cm. Cut surfaces revealed a thinly encapsulated, well-circumscribed lesion with a soft white, gelatinous appearing cut surface. The specimen was entirely submitted for histopathological examination. Routine hematoxylin and eosin stains were performed on formalin-fixed, paraffin-embedded sections and showed a relatively well-circumscribed tumor composed of prominent myxoid stroma with a distinct presence of stellate-shaped bland cells with pyknotic nuclei and virtual absence of blood vessels [
(a) In many areas, the tumor showed the classic appearance of intramuscular myxoma, characterized by a hypocellular tumor with prominent myxoid background, stellate - shaped cells and poorly developed vascularity. (b) In contrast, many foci of increased cellularity and vascularity (arrows) were identified. Note the lack of nuclear atypia, necrosis, and mitotic activity. (H and E, ×20 objective)
As recurrence is very uncommon for such tumors after complete excision, no other therapeutic intervention was recommended. Due to the rather rare diagnosis of cellular myxoma in this locale – with overall dearth of evidence-based clinical recommendations – a close and frequent follow-up surveillance imaging schedule was established for this patient in spite of this entity being described as a benign tumor. To date, 42 months after the surgery, the patient remains neurologically intact, feels well and no recurrence has been observed on sequential imaging [Figure
Unusual sites include the muscles of the head and neck, the forearm, and small muscles of the hand.[
These tumors are usually observed in adults at about 40-70 years of age, with a female predominance.
On histological examination, a unique hypocellular tumor with striking myxoid background and almost absent vasculature is very characteristic. The tumor lacks nuclear atypia, necrosis, and prominent mitotic activity.
Differential diagnosis include low-grade myxofibrosarcoma, low-grade fibromyxoid sarcoma, myxoid liposarcoma, and myxoid neurothecomas.[
Intramuscular myxoma is a benign lesion, and surgery is considered curative, as seems to be the case with our patient, with rare reported cases of local recurrence. Although part of the general “myxoid” family of tumors, these lesions are not associated with the Carney complex,[
Although cellular myxomas are only rarely encountered in the practice of neurosurgery, neurosurgeons should be aware of this entity. Despite the fact that the increase in cellularity may raise concerns about potential aggressiveness of such lesions, previous cases show that complete surgical excision of these lesions is apparently curative and should be seen as the treatment of choice until longer follow up data are available examining outcomes of a larger cohort.
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