Rohin Singh, Maziyar Kalani
  1. Department of Neurosurgery, Mayo Clinic, Scottsdale, Arizona, United States.


Copyright: © 2021 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Rohin Singh, Maziyar Kalani. Cervical intradural intramedullary collision tumor of schwannoma and hemangioblastoma origin. 14-Apr-2021;12:155

How to cite this URL: Rohin Singh, Maziyar Kalani. Cervical intradural intramedullary collision tumor of schwannoma and hemangioblastoma origin. 14-Apr-2021;12:155. Available from:

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Background: Primary spinal tumors are rare benign lesions that represent around 2–4% of all central nervous system neoplasms.[1,2] Intradural intramedullary tumors are predominately glial in origin and are most commonly astrocytomas or ependymomas. Intradural extramedullary tumors, on the other hand, are usually neurofibromas, schwannomas, or meningiomas.[2] Here, we report the case of an intradural intramedullary collision tumor of schwannoma-hemangioblastoma origin.

Case Description: A 61-year-old female presented with a 2-year history of the right arm numbness, weakness, and tingling. She reported some lower extremity numbness but an otherwise normal neurological examination. She had a prior carpal tunnel release that did not alleviate her symptoms. Noncontrast MRI of the cervical spine demonstrated a holocord syrinx from C2 to C7 and spondylolisthesis from C4 to C5. MRI with contrast then displayed an enhancing nodule behind the vertebral body of C4. A standard posterior approach and subperiosteal dissection were performed. Lateral mass screws were placed at C3-C5, and the laminectomy was performed en bloc. Intraoperative ultrasound was used to locate the lesion, and intraoperative dorsal column mapping was used to identify the midline before performing a midline myelotomy. The arachnoid over the lesion was opened and an extracapsular dissection was performed. Hemostasis was obtained, and a watertight dural closure was performed.

Conclusion: The patient tolerated the procedure well and achieved relief from cervical myelopathy symptoms. Pathology indicated positive biomarkers for S-100, SOX10, and NSE indicating a schwannoma hemangioblastoma collision tumor. This is unusual in its nature given two benign lesions with differing underlying cell types of origin.

Keywords: Collision tumor, Hemangioblastoma, Intradural intramedullary, Schwannoma, Spinal tumor



0:32 – Pre-operative imaging findings.

1:17 – Risks and benefits of procedure.

3:01 – Operation.

4:54 – Disease background.

5:30 – Post-operative imaging findings.

Declaration of patient consent

Patient’s consent not required as patients identity is not disclosed or compromised.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

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1. Caro-Osorio E, Herrera-Castro JC, Barbosa-Quintana A, Benvenutti-Regato M. Primary Spinal cord small-cell glioblastoma: Case report and literature review. World Neurosurg. 2018. 118: 69-70

2. Grimm S, Chamberlain MC. Adult primary spinal cord tumors. Expert Rev Neurother. 2009. 9: 1487-95

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