Complete bilateral blindness associated with ruptured anterior communicating artery aneurysm: A literature review and illustrative case
- Department of Neurosurgery, University of Baghdad, College of Medicine, Baghdad, Iraq
- Department of Neurosurgery, University of Al-Nahrain, College of Medicine, Baghdad, Iraq
- Department of Neurosurgery, University of Babylon, College of Medicine, Babil, Iraq
- Department of Neurosurgery, Neurosurgery Teaching Hospital, Baghdad, Iraq
- Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio, United States.
Samer S. Hoz, Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio, United States.
DOI:10.25259/SNI_930_2022Copyright: © 2022 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Teeba A. Al-Ageely1, Mustafa Ismail1, Noor M. Akar2, Rokaya H. Abdalridha3, Mohammed A. ALAli1, Jaber H. Obaid2, Muthanna N. Abdulqader4, Samer S. Hoz5, Norberto Andaluz5. Complete bilateral blindness associated with ruptured anterior communicating artery aneurysm: A literature review and illustrative case. 25-Nov-2022;13:551
How to cite this URL: Teeba A. Al-Ageely1, Mustafa Ismail1, Noor M. Akar2, Rokaya H. Abdalridha3, Mohammed A. ALAli1, Jaber H. Obaid2, Muthanna N. Abdulqader4, Samer S. Hoz5, Norberto Andaluz5. Complete bilateral blindness associated with ruptured anterior communicating artery aneurysm: A literature review and illustrative case. 25-Nov-2022;13:551. Available from: https://surgicalneurologyint.com/?post_type=surgicalint_articles&p=12023
Background: Anterior communicating artery (AcomA) aneurysms are considered one of the most common intracranial aneurysms, contributing to approximately 40% of the subarachnoid hemorrhages related to aneurysmal rupture. Aneurysms of the anterior circulation are commonly present with visual defects varying in their nature according to the aneurysmal site. However, complete bilateral vision loss associated with AcomA aneurysms is a significantly rare finding. We are reporting a case of complete bilateral blindness in a patient with a ruptured AcomA aneurysm with a literature review.
Methods: We conducted a PubMed Medline database search by the following combined formula of subjects’ headings: (((Intracranial Aneurysm [MeSH Terms]) AND (AcomA Aneurysm [Title/Abstract])) AND [(Vision loss OR Blindness [Text Word])) AND (case reports [Filter]). Additional articles were searched through the reference lists of the included articles.
Results: Our review yielded a total of five cases. All the present cases revealed unilateral blindness only, and their outcomes after treatment vary from recovery of vision to unchanged complete vision loss – none of the cases found in the literature presented with bilateral blindness.
Conclusion: AcomA aneurysms can be associated with visual loss in some cases. However, usually, the defect is unilateral. Studies of the visual defects, including potential bilateral complete blindness associated with rupture inferiorly, directed AcomA aneurysm, should be highlighted.
Keywords: Anterior communicating artery aneurysms, Blindness, Intracranial aneurysms, Vision loss
The anterior communicating artery (AcomA) is one of the most common sites of intracranial aneurysms, and it is considered the most common site for aneurysmal rupture, accounting for approximately 40% of aneurysmal subarachnoid hemorrhage (SAH).[
Here, we report a unique case of bilateral complete vision loss associated with an inferiorly directing AcomA aneurysm, along with a review of the literature on the related cases.
A completely healthy 40-year-old female presented with sudden severe headache, neck stiffness, fever, nausea, and complete bilateral blindness with no history of loss of consciousness and was vitally stable. The patient had completely intact vision and was neurologically intact before the presentation. An imaging assessment was performed initially, her computed tomography (CT) scan showed an interhemispheric SAH, and the CT angiography showed a medium-sized inferiorly directing (AcomA) aneurysm [
(a) Preoperative plain axial computed tomography scan showing subarachnoid hemorrhage in the interhemispheric fissure. (b) Preoperative sagittal magnetic resonance imaging shows the inferiorly directing aneurysm, the hyperintense lesion above it is a hematoma, while the hyperintense horizontal line below it is the optic chiasm. (c) Preoperative sagittal section cranial computed tomographic angiography showing the inferiorly directed anterior communicating artery aneurysm.
A decision for management with surgical clipping was made. During surgery, it was observed that the inferiorly directing aneurysm was adherent to the optic chiasm, and the optic nerve had normal vascularity [
We conducted a PubMed Medline database search by the following combined formula of subjects headings: (((Intracranial Aneurysm [MeSH Terms]) AND (AcomA Aneurysm [Title/Abstract])) AND [(Vision loss OR Blindness [Text Word])) AND (case reports [Filter]). Additional articles were searched through the reference lists of the included articles. We followed the Natural Course of Unruptured Cerebral Aneurysms in a Japanese Cohort Study classification of aneurysms by size based on rupture rates: small (5> mm), medium (5–10 mm), large (10–25 mm), and gigantic (>25 mm).[
A total of 18 cases were found in the relevant literature. Moreover, excluding cases unrelated to AcomA aneurysms and those with vision loss as a postoperative complication, we have selected only five cases in the literature reporting AcomA aneurysms presenting with vision loss. All the cases reported showed one-sided blindness, and no case in the literature reported bilateral vision loss. According to the reported cases [
Intracranial aneurysms arising in the anterior circulation are closely related to the anterior visual pathway, including the ophthalmic artery, the supraclinoid segment of the internal carotid artery (ICA), and ICA bifurcation. In addition, the majority of these aneurysms are large to medium sized, resulting in significant compression of the visual pathway, leading to the observed visual defects.[
Despite the mechanism of the blindness still being unknown, ischemia caused by the presence of the aneurysm plays an essential role in the visual field defects as it was found that the capillary network of the optic chiasm receives its blood supply from the anterior cerebral artery and AcomA and any disruption in their blood flow might lead to ischemic effects in the optic chiasm.[
The most common visual defect associated with intracranial aneurysms is bilateral field deficits or bitemporal hemianopia caused by compression over the optic chiasm. In contrast, monocular visual loss is the rarest.[
Surgical clipping is the usual treatment of intracranial aneurysm that causes visual manifestations by clipping of the aneurysmal neck followed by hematoma or thrombus removal from the sac of the aneurysm, causing compression of the visual pathway. Surgical clipping was found to be a better option for recovery than endovascular coiling due to compression relief in surgical clipping, while the mass effect is not usually rapidly resolved by endovascular coiling.[
We reviewed the literature for the cases of AcomA aneurysms associated with blindness and their management and outcomes. The results were scarce, and all the cases presented unilateral vision loss. The AcomA aneurysm was directed anteroinferior in two cases, inferior and to the left in two cases, and unreported direction in the remaining case. The aneurysmal rupture was reported in three of the mentioned cases, while the other two cases did not involve aneurysm rupture complicating the pre- or intraoperative course. In the reported cases, the intraoperative view of the aneurysms showed a direct effect on the optic chiasm or the optic nerve.
The postoperative period of the reported cases went uneventful except for one in which the postoperative course was complicated and resulted in aphasia and right-sided hemiplegia. Regarding the outcome, vision loss persisted in three of the reported cases. Vision improvement was seen in two cases during the follow-up period despite eliminating the aneurysm and confirming the absence of aneurysmal recurrence.[
AcomA aneurysms, although very common, are rarely associated with vision loss as the nature of these aneurysms causes them to rupture before leading to compression over visual pathways. In our case report, we present the only case of complete bilateral blindness associated with an AcomA aneurysm that persisted after the treatment with surgical clipping of the aneurysm.
The exact portion of AcomA aneurysms representing a cause for bilateral vision loss is not yet determined in the literature; awareness of this rare presentation of AcomA aneurysm is critical for the early detection and potential salvage of visual function.
Aneurysms of the anterior circulation can be associated with visual field defects that usually resolve after surgical interventions. Visual loss is a rare phenomenon to be associated with ruptured AcomA aneurysms. We present a case demonstrating a possible complete bilateral blindness due to a ruptured AcomA aneurysm. Further studies are highly encouraged for a better understanding and prediction of the course of treatment and recovery.
Patients’ consent not required as patients’ identities were not disclosed or compromised.
There are no conflicts of interest
The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Journal or its management. The information contained in this article should not be considered to be medical advice; patients should consult their own physicians for advice as to their specific medical needs.
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